Survival after autologous versus allogeneic transplantation in patients with relapsed and refractory Hodgkin lymphoma

被引：3

作者：

Fakhri, Bita ^{[1
]}

Yilmaz, Elif ^{[2
]}

Gao, Feng ^{[3
]}

Ambinder, Richard F. ^{[4
]}

Jones, Richard ^{[4
]}

Bartlett, Nancy L. ^{[1
]}

Cashen, Amanda ^{[1
]}

Wagner-Johnston, Nina ^{[4
]}

机构：

[1] Washington Univ, Dept Med, Div Med Oncol, Sch Med, St Louis, MO 63130 USA

[2] George Washington Univ, Sch Med & Hlth Sci, Div Hematol & Oncol, Dept Med, Washington, DC 20052 USA

[3] Washington Univ, Sch Med, Dept Surg, Div Publ Hlth Sci, St Louis, MO 63110 USA

[4] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

来源：

LEUKEMIA & LYMPHOMA | 2021年 / 62卷 / 10期

关键词：

Autologous hematopoietic cell transplantation; allogeneic hematopoietic cell transplantation; relapsed Hodgkin lymphoma; STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; BRENTUXIMAB VEDOTIN; SALVAGE THERAPY; SINGLE-ARM; NIVOLUMAB; PEMBROLIZUMAB; CHEMOTHERAPY; DISEASE; CYCLOPHOSPHAMIDE;

D O I：

10.1080/10428194.2021.1927016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

For relapsed Hodgkin lymphoma, salvage chemotherapy followed by auto-HCT is the standard of care. It is important to identify subpopulations who could benefit from allo-HCT. This retrospective analysis included 277 patients with rrHL who underwent first transplant with auto-HCT or allo-HCT between 2007-2017. Patients in the auto-HCT cohort (N = 218) were older, more likely to be in CR at the time of transplant and receive maintenance therapy post-transplant. Patients who underwent allo-HCT (N = 59) had a higher MSKCC relapse score. Factors associated with an inferior PFS and OS included early relapse, advanced stage, extranodal involvement and not achieving CR following salvage chemotherapy. After controlling for these 4 risk factors and MSKCC score, PFS (p = 0.112) or OS (p = 0.256) was not affected by the choice of transplant. In patients with >= 3 high risk features, the 4-year PFS was 51% in the allo-HCT vs. 39% (p = 0.107) in the auto-HCT cohort.

引用

页码：2408 / 2415

页数：8

共 40 条

[1] Lower Graft-versus-Host Disease and Relapse Risk in Post-Transplant Cyclophosphamide Based Haploidentical versus Matched Sibling Donor Reduced-Intensity Conditioning Transplant for Hodgkin Lymphoma [J].

Ahmed, Sairah ;

Kanakry, Jennifer A. ;

Ahn, Kwang W. ;

Litovich, Carlos ;

Abdel-Azim, Hisham ;

Aljurf, Mahmoud ;

Bacher, Vera Ulrike ;

Bejanyan, Nelli ;

Cohen, Jonathon B. ;

Farooq, Umar ;

Fuchs, Ephraim J. ;

Bolanos-Meade, Javier ;

Ghosh, Nilanjan ;

Herrera, Alex F. ;

Hossain, Nasheed M. ;

Inwards, David ;

Kanate, Abraham S. ;

Martino, Rodrigo ;

Munshi, Pashna N. ;

Murthy, Hemant ;

Mussetti, Alberto ;

Nieto, Yago ;

Perales, Miguel-Angel ;

Romee, Rizwan ;

Savani, Bipin N. ;

Seo, Sachiko ;

Wirk, Baldeep ;

Yared, Jean A. ;

Sureda, Ana ;

Fenske, Timothy S. ;

Hamadani, Mehdi .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2019, 25 (09) :1859-1868

[2] Long-term results of blood and marrow transplantation for Hodgkin's lymphoma [J].

Akpek, G ;

Ambinder, RF ;

Piantadosi, S ;

Abrams, RA ;

Brodsky, RA ;

Vogelsang, GB ;

Zahurak, ML ;

Fuller, D ;

Miller, CB ;

Noga, SJ ;

Fuchs, E ;

Flinn, IW ;

O'Donnell, P ;

Seifter, EJ ;

Mann, RB ;

Jones, RJ .

JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (23) :4314-4321

[3] PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma [J].

Ansell, Stephen M. ;

Lesokhin, Alexander M. ;

Borrello, Ivan ;

Halwani, Ahmad ;

Scott, Emma C. ;

Gutierrez, Martin ;

Schuster, Stephen J. ;

Millenson, Michael M. ;

Cattry, Deepika ;

Freeman, Gordon J. ;

Rodig, Scott J. ;

Chapuy, Bjoern ;

Ligon, Azra H. ;

Zhu, Lili ;

Grosso, Joseph F. ;

Kim, Su Young ;

Timmerman, John M. ;

Shipp, Margaret A. ;

Armand, Philippe .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (04) :311-319

[4] Programmed Death-1 Blockade With Pembrolizumab in Patients With Classical Hodgkin Lymphoma After Brentuximab Vedotin Failure [J].

Armand, Philippe ;

Shipp, Margaret A. ;

Ribrag, Vincent ;

Michot, Jean-Marie ;

Zinzani, Pier Luigi ;

Kuruvilla, John ;

Snyder, Ellen S. ;

Ricart, Alejandro D. ;

Balakumaran, Arun ;

Rose, Shelonitda ;

Moskowitz, Craig H. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (31) :3733-+

[5] Tandem autologous-reduced intensity allogeneic stem cell transplantation in high-risk relapsed Hodgkin lymphoma: a retrospective study of the Lymphoma Working Party-EBMT [J].

Bento, Leyre ;

Boumendil, Ariane ;

Finel, Herve ;

Khvedelidze, Irma ;

Blaise, Didier ;

Fegueux, Nathalie ;

Castagna, Luca ;

Forcade, Edouard ;

Chevallier, Patrice ;

Mordini, Nicola ;

Brice, Pauline ;

Deconinck, Eric ;

Gramatzki, Martin ;

Corradini, Paolo ;

Hunault, Mathilde ;

Musso, Maurizio ;

Tsoulkani, Anna ;

Caballero, Dolores ;

Nati, Sandro ;

Montoto, Silvia ;

Sureda, Anna .

BONE MARROW TRANSPLANTATION, 2021, 56 (03) :655-663

[6]

Castagna L, 2017, BONE MARROW TRANSPL, V52, P683, DOI 10.1038/bmt.2016.348

[7] Phase II Study of the Efficacy and Safety of Pembrolizumab for Relapsed/Refractory Classic Hodgkin Lymphoma [J].

Chen, Robert ;

Zinzani, Pier Luigi ;

Fanale, Michelle A. ;

Armand, Philippe ;

Johnson, Nathalie A. ;

Brice, Pauline ;

Radford, John ;

Ribrag, Vincent ;

Molin, Daniel ;

Vassilakopoulos, Theodoros P. ;

Tomita, Akihiro ;

von Tresckow, Bastian ;

Shipp, Margaret A. ;

Zhang, Yinghua ;

Ricart, Alejandro D. ;

Balakumaran, Arun ;

Moskowitz, Craig H. .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (19) :2125-+

[8] Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma [J].

Connors, J. M. ;

Jurczak, W. ;

Straus, D. J. ;

Ansell, S. M. ;

Kim, W. S. ;

Gallamini, A. ;

Younes, A. ;

Alekseev, S. ;

Illes, A. ;

Picardi, M. ;

Lech-Maranda, E. ;

Oki, Y. ;

Feldman, T. ;

Smolewski, P. ;

Savage, K. J. ;

Bartlett, N. L. ;

Walewski, J. ;

Chen, R. ;

Ramchandren, R. ;

Zinzani, P. L. ;

Cunningham, D. ;

Rosta, A. ;

Josephson, N. C. ;

Song, E. ;

Sachs, J. ;

Liu, R. ;

Jolin, H. A. ;

Huebner, D. ;

Radford, J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (04) :331-344

[9] Allo-HSCT in transplant-naive patients with Hodgkin lymphoma: a single-arm, multicenter study [J].

Das-Gupta, Emma ;

Thomson, Kirsty J. ;

Bloor, Adrian J. C. ;

Clark, Andrew D. ;

Mackinnon, Stephen ;

Kayani, Irian ;

Clifton-Hadley, Laura ;

Patrick, Pip ;

El-Mehidi, Nadjet ;

Lawrie, Anthony ;

Kirkwood, Amy A. ;

Russell, Nigel H. ;

Linch, David C. ;

Peggs, Karl S. .

BLOOD ADVANCES, 2019, 3 (24) :4264-4270

[10] Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide Using Non-First-Degree Related Donors [J].

Elmariah, Hany ;

Kasamon, Yvette L. ;

Zahurak, Marianna ;

Macfarlane, Karen W. ;

Tucker, Noah ;

Rosner, Gary L. ;

Bolanos-Meade, Javier ;

Fuchs, Ephraim J. ;

Wagner-Johnston, Nina ;

Swinnen, Lode J. ;

Huff, Carol Ann ;

Matsui, William H. ;

Gladstone, Douglas E. ;

McCurdy, Shannon R. ;

Borrello, Ivan ;

Gocke, Christian B. ;

Shanbhag, Satish ;

Cooke, Kenneth R. ;

Ali, Syed Abbas ;

Brodsky, Robert A. ;

DeZern, Amy E. ;

Luznik, Leo ;

Jones, Richard J. ;

Ambinder, Richard F. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2018, 24 (05) :1099-1102

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