Synthesis of Thienopyrimidines and their Antipsychotic Activity

被引：19
|
作者：
Sharma, Chanchal [1 ]
Yerande, Swapnil [1 ]
Chavan, Rajashree [1 ]
Bhosale, A. V. [1 ]
机构：
[1] Seth Govind Raghunath Sable Coll Pharm, Poona Dist Educ Associat, Dept Pharmaceut Chem, Pune 412301, Maharashtra, India
来源：
E-JOURNAL OF CHEMISTRY | 2010年 / 7卷 / 02期
关键词：
Gewald product; Thienopyrimidine; Imidoyl chloride; Antipsychotic activity; CONDENSED; 4-CHLOROPYRIMIDINES; DOPAMINE HYPOTHESIS; ACIDIC CONDITIONS; SCHIZOPHRENIA; DERIVATIVES; CLOZAPINE; NITRILES;
D O I：
10.1155/2010/369141
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of thienopyrimidines and related heterocycles were synthesized by refluxing related imidoyl chloride with primary and secondary amines under microwave irradiation and classical heating. The imidoyl chlorides were synthesized from corresponding cyclic imides with phosphorus oxychlorides under microwave irradiation and classical heating. The structures of the compounds were confirmed by FT-IR, NMR. The synthesized compounds were screened for anti psychotic activity.
引用
收藏
页码：655 / 664
页数：10
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