Epithelial stem cells: Turning over new leaves

被引：442
作者：
Blanpain, Cedric [1 ]
Horsley, Valerie [1 ]
Fuchs, Elaine [1 ]
机构：
[1] Rockefeller Univ, Howard Hughes Med Inst, Lab Mammalian Cell Biol & Dev, New York, NY 10021 USA
来源：
CELL | 2007年 / 128卷 / 03期
关键词：
D O I：
10.1016/j.cell.2007.01.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Most epithelial tissues self-renew throughout adult life due to the presence of multipotent stem cells and/or unipotent progenitor cells. Epithelial stem cells are specified during development and are controlled by epithelial-mesenchymal interactions. Despite morphological and functional differences among epithelia, common signaling pathways appear to control epithelial stem cell maintenance, activation, lineage determination, and differentiation. Additionally, deregulation of these pathways can lead to human disorders including cancer. Understanding epithelial stem cell biology has major clinical implications for the diagnosis, prevention, and treatment of human diseases, as well as for regenerative medicine. © 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：445 / 458
页数：14
相关论文
共 104 条
[1]   Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development [J].
Andl, T ;
Ahn, K ;
Kairo, A ;
Chu, EY ;
Wine-Lee, L ;
Reddy, ST ;
Croft, NJ ;
Cebra-Thomas, JA ;
Metzger, D ;
Chambon, P ;
Lyons, KM ;
Mishina, Y ;
Seykora, JT ;
Crenshaw, EB ;
Millar, SE .
DEVELOPMENT, 2004, 131 (10) :2257-2268
[2]   WNT signals are required for the initiation of hair follicle development [J].
Andl, T ;
Reddy, ST ;
Gaddapara, T ;
Millar, SE .
DEVELOPMENTAL CELL, 2002, 2 (05) :643-653
[3]   Notch signaling: Cell fate control and signal integration in development [J].
Artavanis-Tsakonas, S ;
Rand, MD ;
Lake, RJ .
SCIENCE, 1999, 284 (5415) :770-776
[4]   Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium [J].
Barker, N ;
Huls, G ;
Korinek, V ;
Clevers, H .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (01) :29-35
[5]   3 CLONAL TYPES OF KERATINOCYTE WITH DIFFERENT CAPACITIES FOR MULTIPLICATION [J].
BARRANDON, Y ;
GREEN, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2302-2306
[6]   β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/EphrinB [J].
Batlle, E ;
Henderson, JT ;
Beghtel, H ;
van den Born, MMW ;
Sancho, E ;
Huls, G ;
Meeldijk, J ;
Robertson, J ;
van de Wetering, M ;
Pawson, T ;
Clevers, H .
CELL, 2002, 111 (02) :251-263
[7]   Tissue repair and stem cell renewal in carcinogenesis [J].
Beachy, PA ;
Karhadkar, SS ;
Berman, DM .
NATURE, 2004, 432 (7015) :324-331
[8]   IDENTIFICATION AND BEHAVIOR OF LABEL-RETAINING CELLS IN ORAL-MUCOSA AND SKIN [J].
BICKENBACH, JR .
JOURNAL OF DENTAL RESEARCH, 1981, 60 :1611-1620
[9]   MOLECULAR ASPECTS OF MESENCHYMAL-EPITHELIAL INTERACTIONS [J].
BIRCHMEIER, C ;
BIRCHMEIER, W .
ANNUAL REVIEW OF CELL BIOLOGY, 1993, 9 :511-540
[10]   Clonal analysis of mouse intestinal epithelial progenitors [J].
Bjerknes, M ;
Cheng, H .
GASTROENTEROLOGY, 1999, 116 (01) :7-14
12345678910