CoCl2-promoted TEMPO oxidative homocoupling of indoles: access to tryptanthrin derivatives

被引：13

作者：

Liao, Huiwu ^{[1
]}

Peng, Xiangjun ^{[2
]}

Hu, Dan ^{[1
]}

Xu, Xianyun ^{[2
]}

Huang, Panpan ^{[1
]}

Liu, Qian ^{[2
]}

Liu, Liangxian ^{[1
]}

机构：

[1] Gannan Normal Univ, Dept Chem & Chem Engn, Ganzhou 341000, Jiangxi, Peoples R China

[2] Gannan Med Univ, Sch Pharmaceut Sci, Ganzhou 341000, Jiangxi, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 31期

基金：

中国国家自然科学基金;

关键词：

CATALYZED OXIDATION; POTENT INHIBITORS; AEROBIC OXIDATION; MOLECULAR-OXYGEN; EFFICIENT; TRIMERIZATION; PRINCIPLE; CHEMISTRY; RADICALS; ALCOHOLS;

D O I：

10.1039/c8ob01216d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel TEMPO/CoCl2-promoted aerobic oxidation of indoles was developed. The reaction provided one-step access to tryptanthrin derivatives in moderate to good yields and excellent regioselectivity via a cascade process. The reactions could be carried out under mild reaction conditions with varying functional group tolerance, especially halogen functional groups. Mechanistic studies disclosed that the oxygen atom in the desired product originated from molecular dioxygen.

引用

页码：5699 / 5706

页数：8

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