Antiprotozoal activity of Betulinic acid derivatives

被引：70

作者：

Dominguez-Carmona, D. B. ^{[1
]}

Escalante-Erosa, F. ^{[1
]}

Garcia-Sosa, K. ^{[1
]}

Ruiz-Pinell, G. ^{[2
]}

Gutierrez-Yapu, D. ^{[2
]}

Chan-Bacab, M. J. ^{[3
]}

Gimenez-Turba, A. ^{[2
]}

Pena-Rodriguez, L. M. ^{[1
]}

机构：

[1] Ctr Invest Cient Yucatan, Unidad Biotecnol, Merida 97200, Yucatan, Mexico

[2] UMSA, IIFB, La Paz, Bolivia

[3] Univ Autonoma Campeche, Dept Microbiol Ambiental & Biotecnol, Campeche, Mexico

来源：

PHYTOMEDICINE | 2010年 / 17卷 / 05期

关键词：

Pentalinon andriexii; Betulinic acid; Leishmanicidal; Trypanocidal; Antiplasmodial; POTENTIAL ANTITUMOR; NATURAL-PRODUCTS; TRITERPENES; GROWTH; INHIBITION; ALKALOIDS;

D O I：

10.1016/j.phymed.2009.08.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：379 / 382

页数：4

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