Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review

被引:2
作者
Mazziotta, Francesco [1 ]
Buda, Gabriele [1 ]
Del Giudice, Maria Livia [1 ]
Orciuolo, Enrico [1 ]
Benedetti, Edoardo [1 ]
Masini, Matilde [2 ]
De Tata, Vincenzo [2 ]
Galimberti, Sara [1 ]
Petrini, Mario [1 ]
机构
[1] Pisa Univ Hosp, Hematol Div, I-56126 Pisa, Italy
[2] Pisa Univ, Dept Translat Res & New Technol Med & Surg, I-56126 Pisa, Italy
关键词
immunoglobulin light-chain amyloidosis; multiple myeloma; plasma cell neoplasm; joint diseases; DIAGNOSIS;
D O I
10.3390/hematolrep14010004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a diagnosis of amyloidosis, which had preceded the diagnosis of MM and benefited from MM treatment. Faced with the suspicion of amyloidosis, if confirmed, this can be used to anticipate the diagnosis of MM, and at a more advanced stage, it can benefit from the treatment of the MM.
引用
收藏
页码:19 / 23
页数:5
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