Level of uric acid and uric acid/creatinine ratios in correlation with stage of Parkinson disease

被引：30

作者：

Zhong, Ling-Ling ^{[1
]}

Song, Ya-Qi ^{[2
,3
]}

Tian, Xiang-Yang ^{[1
]}

Cao, Hua ^{[1
]}

Ju, Ke-Ju ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Neurol, 6 Beijing Rd West, Huaian 223300, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Radiat Oncol, Huaian, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Hematol, Huaian, Jiangsu, Peoples R China

来源：

MEDICINE | 2018年 / 97卷 / 26期

关键词：

H-Y classification; Parkinson disease; prognostic factor; uric acid; uric acid/creatinine; URATE; SERUM; RISK; ANTIOXIDANT; PROGRESSION; BIOMARKER; MEN;

D O I：

10.1097/MD.0000000000010967

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study aims to investigate relationship between the level of uric acid (UA) and UA/creatinine ratios (UA/Cr) to the stage of Parkinson disease (PD). A total of 120 cases of PD patients who were admitted in our hospital between 2013 and 2015 were enrolled into this study; these 120 cases of PD patients were divided into 3 groups, according to Hoehn-Yahr (H-Y) classification: early stage (1-2 classification), medium stage (2.5-3 classification), and advanced stage (4-5 classification); UA and UA/Cr level in each group was compared. Then, factors including age, gender, dopamine dosage, UA, and UA/Cr levels were analyzed to find the independent predictive factors of PD by logistic regression. UA and UA/Cr levels in the early and medium stage PD patients were significantly higher than in the advanced stage ones. UA and UA/Cr levels in patients with good prognosis were significantly higher than in the poor ones. UA and UA/Cr levels are negatively correlated with the stages of PD and are independent negatively predicting biological indexes of PD incidence and progression.

引用

页数：4

共 25 条

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