rs12287003 modifies the susceptibility to breast cancer by altering the interactions between KDM2A and miRNAs

Breast cancer is one of the main causes of mortality throughout the world, especially in women. Lysine Demethylase 2A (KDM2A) gene is highly expressed in myoepithelial cells of mammary tissue that eventually contributes to breast tumorigenesis. The purpose of this study was to investigate the association between rs12287003 polymorphic factor of the KDM2A gene and breast cancer incidence. To develop this aim, we used Allele-specific PCR (ASP-PCR) to genotype breast cancer and healthy control samples. The results indicate that rs12287003 allele C was associated with a higher risk of breast cancer, while allele G reduced it. Mechanistically, allele C was shown to broadly attenuate the binding of numerous miRNAs to KDM2A transcripts, potentially inducing the KDM2A upregulation-mediated breast tumorigenesis. The findings of this study may have clinical implications upon validation in other clinical cohorts.