Co(III)(salen)-catalyzed HKR of two stereocentered alkoxy- and azido epoxides: a concise enantioselective synthesis of (S,S)-reboxetine and (+)-epi-cytoxazone

被引：43

作者：

Reddy, R. Santhosh ^{[1
]}

Chouthaiwale, Pandurang V. ^{[1
]}

Suryavanshi, Gurunath ^{[1
]}

Chavan, Vilas B. ^{[1
]}

Sudalai, Arumugam ^{[1
]}

机构：

[1] Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 27期

关键词：

HYDROLYTIC KINETIC RESOLUTION; CYTOKINE MODULATOR; TERMINAL EPOXIDES; STYRYL-LACTONES; CYTOXAZONE; REBOXETINE;

D O I：

10.1039/c0cc00650e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The HKR of racemic syn- or anti- alkoxy- and azido epoxides catalyzed by Co(salen) complex affords a practical access to a series of enantioenriched syn- or anti- alkoxy- and azido epoxides and the corresponding 1,2-diols. This strategy has been successfully employed in the concise, enantioselective synthesis of bioactive molecules such as (S, S)-reboxetine and (+)-epi-cytoxazone.

引用

页码：5012 / 5014

页数：3

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