CPET and cardioesophagectomy: A single centre 10-year experience

被引:9
作者
Benington, Steve [1 ]
Bryan, Angella [1 ,2 ]
Milne, Owen [1 ]
Alkhaffaf, Bilal [3 ,4 ]
机构
[1] Manchester Univ Hosp NHS Fdn Trust, Manchester Royal Infirm, Manchester Acad Hlth Sci Ctr, Dept Anaesthesia & Intens Care, Oxford Rd, Manchester M13 9WL, Lancs, England
[2] Univ Manchester, Cardiovasc Metab & Nutr Sci, Oxford Rd, Manchester M13 9PL, Lancs, England
[3] Manchester Univ Hosp NHS Fdn Trust, Manchester Royal Infirm, Manchester Acad Hlth Sci Ctr, Dept Oesophago Gastr Surg, Oxford Rd, Manchester M13 9WL, Lancs, England
[4] Fac Biol Med & Hlth, Sch Med Sci, Div Canc Sci, Oxford Rd, Manchester M13 9PL, Lancs, England
来源
EJSO | 2019年 / 45卷 / 12期
关键词
CPET; Cardiopulmonary exercise testing; Cardioesophagectomy; Pre-operative assessment; Cardiac ischaemia; LENGTH-OF-STAY; CARDIOPULMONARY RESERVE; RISK-ASSESSMENT; SURGERY; COMPLICATIONS; MORTALITY; MORBIDITY; MANAGEMENT; PREDICTOR; SURVIVAL;
D O I
10.1016/j.ejso.2019.06.013
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction: CPET is a routine investigation prior to cardioesophagectomy. Over a 10-year period 200 patients had CPET before elective cardioesophagectomy. We examine the relationship between CPET and outcomes in these patients. Materials and methods: Complication data were prospectively collected using the Clavien-Dindo system. Logistic regression analysis was used to determine whether 90-day mortality and morbidity were significantly different between fitter and less fit patients. Results: 90-day mortality was 5.5%. In univariate analysis the following factors were associated with a significantly increased risk of death at 90 days: anaerobic threshold <11 ml k g(-1) min(-1) OR (95% CI) = 4.38 (1.23,15.6), p = 0.023; VO2 peak <15 ml kg (-1 )min(-1) O-2 OR (95% CI) = 5.0 (1.42,15.55), p = 0.012; VE/VCO2 > 34 OR (95% CI) = 4.07 (1.19,14.0), p = 0.026; diabetes mellitus OR (95% CI) = 5.76 (1.55,21.35) p = 0.009. In multivariate logistic regression analysis both diabetes (OR = 5.76 [1.55,21.4] p = 0.009) and presence of >= 1 subthreshold CPET value (OR = 6.72 [1.32,29.8] p = 0.021) were significantly associated with increased risk of death at 90 days. Median (95% CI) survival for patients who had a CPET with 'normal' parameters was 1176 (565, 1787) days, compared with 642 (336, 948) days for patients with >= one subthreshold parameter. 15.5% of patients had ECG ischaemia; there were no deaths in this group. Conclusion: Presence of at least one sub-threshold CPET value at pre-operative testing is associated with increased risk of 90-day mortality and shorter long term survival. These results allow us to better define risks during shared decision-making with patients. (C) 2019 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
引用
收藏
页码:2451 / 2456
页数:6
相关论文
共 33 条
[1]   Reducing hospital morbidity and mortality following esophagectomy [J].
Atkins, BZ ;
Shah, AS ;
Hutcheson, KA ;
Mangum, JH ;
Pappas, TN ;
Harpole, DH ;
D'Amico, TA .
ANNALS OF THORACIC SURGERY, 2004, 78 (04) :1170-1176
[2]   Effects of low cardiopulmonary reserve on pancreatic leak following pancreaticoduodenectomy [J].
Ausania, F. ;
Snowden, C. P. ;
Prentis, J. M. ;
Holmes, L. R. ;
Jaques, B. C. ;
White, S. A. ;
French, J. J. ;
Manas, D. M. ;
Charnley, R. M. .
BRITISH JOURNAL OF SURGERY, 2012, 99 (09) :1290-1294
[3]   Exercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing [J].
Belardinelli, R ;
Lacalaprice, F ;
Carle, F ;
Minnucci, A ;
Cianci, G ;
Perna, GP ;
D'Eusanio, G .
EUROPEAN HEART JOURNAL, 2003, 24 (14) :1304-1313
[4]   Meta-analysis of secure randomised controlled trials of β-blockade to prevent perioperative death in non-cardiac surgery [J].
Bouri, Sonia ;
Shun-Shin, Matthew James ;
Cole, Graham D. ;
Mayet, Jamil ;
Francis, Darrel P. .
HEART, 2014, 100 (06) :456-464
[5]  
Chadwick G, 2015, ANN REPORT
[6]   Cardiopulmonary exercise testing and length of stay in patients undergoing major surgery [J].
Clayton, R. A. ;
Bannard-Smith, J. P. ;
Washington, S. J. ;
Wisely, N. ;
Columb, M. ;
Rees, L. .
ANAESTHESIA, 2011, 66 (05) :393-394
[7]   Perioperative statin therapy in patients at high risk for cardiovascular morbidity undergoing surgery: a review [J].
de Waal, B. A. ;
Buise, M. P. ;
van Zundert, A. A. J. .
BRITISH JOURNAL OF ANAESTHESIA, 2015, 114 (01) :44-52
[8]   Effects of extended-release metoprolol succinate inpatients undergoing non-cardiac surgery (POISE trial):: a randomised controlled trial [J].
Devereaux, P. J. ;
Yang, Homer ;
Yusuf, Salim ;
Guyatt, Gordon ;
Leslie, Kate ;
Villar, Juan Carlos ;
Xavier, Denis ;
Chrolavicius, Susan ;
Greenspan, Launi ;
Pogue, Janice ;
Pais, Prem ;
Liu, Lisheng ;
Xu, Shouchun ;
Malaga, German ;
Avezum, Alvaro ;
Chan, Matthew ;
Montori, Victor M. ;
Jacka, Mike ;
Choi, Peter .
LANCET, 2008, 371 (9627) :1839-1847
[9]   Classification of surgical complications - A new proposal with evaluation in a cohort of 6336 patients and results of a survey [J].
Dindo, D ;
Demartines, N ;
Clavien, PA .
ANNALS OF SURGERY, 2004, 240 (02) :205-213
[10]   2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery [J].
Fleisher, Lee A. ;
Fleischmann, Kirsten E. ;
Auerbach, Andrew D. ;
Barnason, Susan A. ;
Beckman, Joshua A. ;
Bozkurt, Biykem ;
Davila-Roman, Victor G. ;
Gerhard-Herman, Marie D. ;
Holly, Thomas A. ;
Kane, Garvan C. ;
Marine, Joseph E. ;
Nelson, M. Timothy ;
Spencer, Crystal C. ;
Thompson, Annemarie ;
Ting, Henry H. ;
Uretsky, Barry F. ;
Wijeysundera, Duminda N. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 64 (22) :E77-E137