Synthesis and evaluation of pyridinium polyoxometalates as anti-HIV-1 agents

被引：25
作者：
Wang, Shunyi [1 ]
Sun, Wuji [1 ]
Hu, Qin [1 ]
Yan, Hong [1 ]
Zeng, Yi [1 ]
机构：
[1] Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Pyridinium polyoxometalates; Human immunodeficiency virus; Synthesis; TZM-bl assay; HUMAN-IMMUNODEFICIENCY-VIRUS; HERPES-SIMPLEX-VIRUS; IN-VITRO; HETEROPOLYOXOTUNGSTATE PM-19; PROTEASE INHIBITION; ANTIVIRAL ACTIVITY; MECHANISM; TYPE-1; HPA-23; SPECIFICITY;
D O I：
10.1016/j.bmcl.2017.04.025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The unique properties of polyoxometalates, such as molecular polarity, redox potential, surface charge distribution, shape and acidity, influence their response of recognition to targeted biological macromolecules. By using PM-19 (K7PTi2W10O40) as a lead-compound, a series of novel pyridinium polyoxometalates (A(7)PTi(2)W(10)O(40)), which hadn't been reported in literatures, were designed and synthesized. The evaluation was conducted using the single-cycle pseudovirus infection assay (TZM-bl assay), CCK8 method was used for determining the cytotoxicity. The results indicated that the designed pyridinium polyoxometalates had a lower toxicity to TZM-bl cells, and showed higher inhibitory activity against HIV 1 virus. (C) 2017 Published by Elsevier Ltd.
引用
收藏
页码：2357 / 2359
页数：3
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