Roles for nuclear organization in the maintenance of genome stability

被引：19

作者：

Nagai, Shigeki ^{[1
]}

Heun, Patrick ^{[2
]}

Gasser, Susan M. ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

[2] Max Planck Inst Immunobiol, D-7800 Freiburg, Germany

来源：

EPIGENOMICS | 2010年 / 2卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

DNA damage; genome stability; nuclear organization; recombination; DOUBLE-STRAND BREAK; RIBOSOMAL DNA; DROSOPHILA-MELANOGASTER; CELL-CYCLE; RECOMBINATIONAL REPAIR; HOMOLOGOUS CHROMOSOME; GENE-EXPRESSION; DAMAGE RESPONSE; DISTINCT ROLES; SIR4; PROTEINS;

D O I：

10.2217/EPI.09.49

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent findings demonstrate that chromatin dynamics and nuclear organization are not only important for gene regulation but also for the maintenance of genome stability. Thanks to novel techniques that allow the visualization of specific chromatin domains in living cells, recent studies have demonstrated that the spatial dynamics of double-strand breaks and modifying enzymes can influence repair. The importance of the spatial organization in the repair of DNA damage has been confirmed by demonstrating that perturbation of nuclear organization can lead to gene amplifications, deletions, translocations and end-to-end telomere fusion events.

引用

页码：289 / 305

页数：17

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