Enantioselective creation of quaternary carbon centers through addition-elimination reaction: Asymmetric nitroolefination of 3-substituted 2-oxindoles

被引：40
作者：
Fuji, K [1 ]
Kawabata, T
Ohmori, T
Shang, MH
Node, M
机构：
[1] Kyoto Univ, Inst Chem Res, Uji 611, Japan
[2] Kyoto Pharmaceut Univ, Kyoto 607, Japan
来源：
HETEROCYCLES | 1998年 / 47卷 / 02期
关键词：
D O I：
10.3987/COM-97-S(N)107
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nitroolefination of 3-substituted 2-oxindoles with nitroenamine (5) afforded the corresponding products having quaternary carbon centers with high ee in good yield. Application of this method to concise syntheses of (-)-esermethole (24) and (-)-pseudophrynaminol (28) is described.
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页码：951 / 964
页数：14
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