Factors associated with long diagnostic delay in celiac disease
被引:79
作者:
Fuchs, Valma
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Univ Tampere, Tampere Ctr Child Hlth Res, FIN-33014 Tampere, Finland
Tampere Univ Hosp, Tampere, FinlandUniv Tampere, Tampere Ctr Child Hlth Res, FIN-33014 Tampere, Finland
Fuchs, Valma
[1
,2
]
Kurppa, Kalle
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机构:
Univ Tampere, Tampere Ctr Child Hlth Res, FIN-33014 Tampere, Finland
Tampere Univ Hosp, Tampere, FinlandUniv Tampere, Tampere Ctr Child Hlth Res, FIN-33014 Tampere, Finland
Kurppa, Kalle
[1
,2
]
Huhtala, Heini
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机构:
Univ Tampere, Tampere Sch Hlth Sci, FIN-33014 Tampere, FinlandUniv Tampere, Tampere Ctr Child Hlth Res, FIN-33014 Tampere, Finland
Huhtala, Heini
[3
]
Collin, Pekka
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机构:
Univ Tampere, Tampere Univ Hosp, Sch Med, Dept Gastroenterol & Alimentary Tract Surg, FIN-33014 Tampere, FinlandUniv Tampere, Tampere Ctr Child Hlth Res, FIN-33014 Tampere, Finland
Collin, Pekka
[4
]
Maki, Markku
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机构:
Univ Tampere, Tampere Ctr Child Hlth Res, FIN-33014 Tampere, Finland
Tampere Univ Hosp, Tampere, FinlandUniv Tampere, Tampere Ctr Child Hlth Res, FIN-33014 Tampere, Finland
Maki, Markku
[1
,2
]
论文数: 引用数:
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机构:
Kaukinen, Katri
[5
,6
]
机构:
[1] Univ Tampere, Tampere Ctr Child Hlth Res, FIN-33014 Tampere, Finland
[2] Tampere Univ Hosp, Tampere, Finland
[3] Univ Tampere, Tampere Sch Hlth Sci, FIN-33014 Tampere, Finland
[4] Univ Tampere, Tampere Univ Hosp, Sch Med, Dept Gastroenterol & Alimentary Tract Surg, FIN-33014 Tampere, Finland
[5] Tampere Univ Hosp, Sch Med, Dept Internal Med, Tampere, Finland
Objective. Here, we investigated the factors associated with long diagnostic delay in celiac disease and the impact of the national Current Care Guidelines in reducing the delay. Material and methods. This population-based study involved 825 adult celiac disease patients. The diagnosis was considered delayed when the interval between first symptoms and diagnosis was > 10 years. The patients were asked about the duration and type of symptoms before diagnosis, time and site (tertiary, secondary, or primary care) of the diagnosis, family history of the disease, and presence of significant comorbidities. Analysis was performed by binary logistic regression. Results. Altogether, 261 (32%) out of 825 participants reported a diagnostic delay of > 10 years. Female gender, neurological or musculoskeletal disorders and presence of diarrhea, abdominal pain, and malabsorption were associated with prolonged delay. Male gender, diagnosis after the introduction of the first Current Care Guidelines in 1997, and being detected by serological screening, and family history of celiac disease were associated with a lower risk of delayed diagnosis. Factors not associated with the delay were site of diagnosis, age, and presence of dermatitis herpetiformis, type 1 diabetes, or thyroidal disease. Conclusion. The number of long diagnostic delays in celiac disease has decreased over the past decades. The shift of diagnostics from secondary and tertiary care to primary care has not been detrimental. National guidelines together with increased awareness and active screening in at-risk groups of celiac disease are important in these circumstances.
机构:
CEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, SpainCEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, Spain
Ballestero-Fernandez, Catalina
Varela-Moreiras, Gregorio
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机构:
CEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, Spain
Spanish Nutr Fdn FEN, C Gen Alvarez de Castro 20,1 Pta, Madrid 28010, SpainCEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, Spain
Varela-Moreiras, Gregorio
Ubeda, Natalia
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h-index: 0
机构:
CEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, SpainCEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, Spain
Ubeda, Natalia
Alonso-Aperte, Elena
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h-index: 0
机构:
CEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, SpainCEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, Spain
机构:
St Johns Univ, Coll Pharm & Hlth Sci, New York, NY USA
Columbia Univ, Med Ctr, NewYork Presbyterian Hosp, New York, NY USASt Johns Univ, Coll Pharm & Hlth Sci, New York, NY USA
机构:
Univ British Columbia, Dept Med Gastroenterol, Vancouver, BC V6T 1W5, CanadaUniv British Columbia, Dept Med Gastroenterol, Vancouver, BC V6T 1W5, Canada
机构:
CEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, SpainCEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, Spain
Ballestero-Fernandez, Catalina
Varela-Moreiras, Gregorio
论文数: 0引用数: 0
h-index: 0
机构:
CEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, Spain
Spanish Nutr Fdn FEN, C Gen Alvarez de Castro 20,1 Pta, Madrid 28010, SpainCEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, Spain
Varela-Moreiras, Gregorio
Ubeda, Natalia
论文数: 0引用数: 0
h-index: 0
机构:
CEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, SpainCEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, Spain
Ubeda, Natalia
Alonso-Aperte, Elena
论文数: 0引用数: 0
h-index: 0
机构:
CEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, SpainCEU Univ, Univ San Pablo CEU, Fac Farm, Dept Pharmaceut & Hlth Sci, Alcorcon 28925, Spain
机构:
St Johns Univ, Coll Pharm & Hlth Sci, New York, NY USA
Columbia Univ, Med Ctr, NewYork Presbyterian Hosp, New York, NY USASt Johns Univ, Coll Pharm & Hlth Sci, New York, NY USA
机构:
Univ British Columbia, Dept Med Gastroenterol, Vancouver, BC V6T 1W5, CanadaUniv British Columbia, Dept Med Gastroenterol, Vancouver, BC V6T 1W5, Canada