Iridium Complex-Catalyzed Transfer Hydrogenation of N-Heteroarenes and Tentative Asymmetric Synthesis

被引：28

作者：

Ouyang, Lu ^{[1
]}

Xia, Yanping ^{[1
]}

Liao, Jianhua ^{[1
]}

Miao, Rui ^{[1
]}

Yang, Xiao ^{[1
]}

Luo, Renshi ^{[1
]}

机构：

[1] Gannan Med Univ, Sch Pharm, Ganzhou 341000, Jiangxi, Peoples R China

来源：

ACS OMEGA | 2021年 / 6卷 / 15期

基金：

中国国家自然科学基金;

关键词：

FORMIC-ACID; IRON CATALYST; QUINOLINES; HETEROCYCLES; DEHYDROGENATION; REDUCTION; MECHANISM; OXAMNIQUINE; CHEMISTRY; ALDEHYDES;

D O I：

10.1021/acsomega.1c00868

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An iridium-catalyzed transfer hydrogenation of N-heteroarenes to access a series of substituted 1,2,3,4-tetrahydroquinoline derivatives in excellent yields is disclosed. This transformation is distinguished with water-soluble and air-stable iridium complexes as the catalyst, formic acid as the hydrogen source, mild reaction conditions, and broad functional group compatibility. Most importantly, a tentative chiral N,N-chelated Cp*Ir(III) complex-catalyzed enantioselective transfer hydrogenation is also presented, affording chiral products in excellent yields and good enantioselectivities.

引用

页码：10415 / 10427

页数：13

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