A nanotheranostic agent based on Nd3+-doped YVO4 with blood-brain-barrier permeability for NIR-II fluorescence imaging/magnetic resonance imaging and boosted sonodynamic therapy of orthotopic glioma

被引：81

作者：

Lv, Zhijia ^{[1
,2
,3
]}

Jin, Longhai ^{[4
]}

Cao, Yue ^{[5
]}

Zhang, Hao ^{[1
,2
]}

Xue, Dongzhi ^{[1
,2
]}

Yin, Na ^{[1
,2
]}

Zhang, Tianqi ^{[4
]}

Wang, Yinghui ^{[1
,2
]}

Liu, Jianhua ^{[4
]}

Liu, Xiaogang ^{[6
]}

Zhang, Hongjie ^{[1
,2
,3
,7
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem CIAC, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China

[2] Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China

[3] Chinese Acad Sci, Ganjiang Innovat Acad, Ganzhou 341000, Jiangxi, Peoples R China

[4] Second Hosp Jilin Univ, Dept Radiol, Changchun 130041, Peoples R China

[5] First Hosp Jilin Univ, Dept Neurosurg, Changchun 130041, Peoples R China

[6] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[7] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

来源：

LIGHT-SCIENCE & APPLICATIONS | 2022年 / 11卷 / 01期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

NANOPARTICLES; LACTOFERRIN;

D O I：

10.1038/s41377-022-00794-9

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The specific diagnosis and treatment of gliomas is a primary challenge in clinic due to their high invasiveness and blood-brain barrier (BBB) obstruction. It is highly desirable to find a multifunctional agent with good BBB penetration for precise theranostics. Herein, we design and construct a core-shell structured nanotheranostic agent (YVO4:Nd3+-HMME@MnO2-LF, marked as YHM) with YVO4:Nd3+ particles as the core and MnO2 nanosheets as the shell. Sonosensitizer hematoporphyrinmonomethyl ether (HMME) and lactoferrin (LF) were further loaded and modified on the surface, giving it a good ability to cross the BBB, near-infrared fluorescence imaging in the second window (NIR-II)/magnetic resonance imaging (MRI) bimodality, and highly efficient sonodynamic therapy (SDT) of orthotopic gliomas. The YVO4:Nd3+ (25%) core exhibited good NIR-II fluorescence properties, enabling YHM to act as promising probes for NIR-II fluorescence imaging of vessels and orthotopic gliomas. MnO2 shell can not only provide O-2 in the tumor microenvironments (TME) to significantly improve the healing efficacy of SDT, but also release Mn2+ ions to achieve T-1-weight MRI in situ. Non-invasive SDT can effectively restrain tumor growth. This work not only demonstrates that multifunctional YHM is promising for diagnosis and treatment of orthotopic glioma, but also provides insights into exploring the theranostic agents based on rare earth-doped yttrium vanadate nanoparticles.

引用

页数：10