Does defibrotide prophylaxis decrease the risk of acute graft versus host disease following allogeneic hematopoietic cell transplantation?

被引：14

作者：

Tekgunduz, Emre ^{[1
]}

Kaya, Ali Hakan ^{[1
]}

Bozdag, Sinem Civriz ^{[2
]}

Kocubaba, Erife ^{[1
]}

Kayikci, Omur ^{[1
]}

Namdaroglu, Sinem ^{[1
]}

Ugur, Bilge ^{[1
]}

Akpinar, Seval ^{[1
]}

Batgi, Hikmetullah ^{[1
]}

Bekdemir, Filiz ^{[1
]}

Altuntas, Fevzi ^{[3
]}

机构：

[1] Ankara Oncol Educ & Res Hosp, Hematol & Stem Cell Transplantat Clin, TR-06200 Ankara, Turkey

[2] Ankara Univ, Fac Med, Dept Internal Med, Div Hematol, TR-06100 Ankara, Turkey

[3] Yildirim Beyazit Univ, Fac Med, Dept Internal Med, Div Hematol, Ankara, Turkey

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2016年 / 54卷 / 01期

关键词：

Acute graft-versus-host disease; Defibrotide; Acute GVHD; Prophylaxis; VENOOCCLUSIVE DISEASE; CLINICAL-TRIALS; ACUTE GVHD; BLOOD;

D O I：

10.1016/j.transci.2016.01.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is some preliminary evidence, that veno-occlusive disease prophylaxis with defibrotide (DF) may also have a role in decreasing risk of acute graft-versus-host disease (aGvHD) by preventing tissue damage. In this study, we aimed to investigate the role of DF prophylaxis on the development of aGvHD at D + 180. One hundred ninety-five consecutive adult patients receiving allogeneic HCT were retrospectively evaluated in 3 groups: no DF, DF/post-Ha (DF D +1 to D + 14) and DF/pre-HCT (DF for 14 days concurrently with conditioning). The total (p: 0.057) and grades III/IV (p: 0.051) aGvHD rates at D + 180 were 46.5%, 40%, 25.5% and 15.5%, 11.2%, 0% in patients on no DF, DF/post-HCT and DF/pre-HCT. DF may have a role in decreasing incidence and severity of aGvHD, especially if used concurrently with conditioning regimen. (c) 2016 Elsevier Ltd. All rights reserved.

引用

页码：30 / 34

页数：5

共 12 条

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