Oxysterols: An emerging class of broad spectrum antiviral effectors

被引:84
作者
Lembo, David [1 ]
Cagno, Valeria [1 ]
Civra, Andrea [1 ]
Poli, Giuseppe [1 ]
机构
[1] Univ Turin, Dept Clin & Biol Sci, San Luigi Gonzaga Hosp, I-10043 Turin, Italy
关键词
Oxysterols; 25-Hydroxycholesterol; 27-Hydroxycholesterol; Enveloped virus; Non-enveloped viruses; Antiviral; Innate immunity; HEPATITIS-C VIRUS; DENSITY-LIPOPROTEIN RECEPTOR; FATTY-ACID SYNTHASE; BINDING-PROTEIN; RNA REPLICATION; HUMAN HEPATOCYTES; 25-HYDROXYCHOLESTEROL; CHOLESTEROL; INFECTION; METABOLISM;
D O I
10.1016/j.mam.2016.04.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oxysterols are a family of cholesterol oxidation derivatives that contain an additional hydroxyl, epoxide or ketone group in the sterol nucleus and/or a hydroxyl group in the side chain. The majority of oxysterols in the blood are of endogenous origin, derived from cholesterol via either enzymatic or non-enzymatic mechanisms. A large number of reports demonstrate multiple physiological roles of specific oxysterols. One such role is the inhibition of viral replication. This biochemical/biological property was first characterised against a number of viruses endowed with an external lipid membrane (enveloped viruses), although antiviral activity has since been observed in relation to several non-enveloped viruses. In the present paper, we review the recent findings about the broad antiviral activity of oxysterols against enveloped and non-enveloped human viral pathogens, and provide an overview of their putative antiviral mechnism(s). (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:23 / 30
页数:8
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