The Role of Radiation Therapy for Pancreatic Cancer in the Adjuvant and Neoadjuvant Settings

被引：38

作者：

Badiyan, Shahed N. ^{[1
]}

Molitoris, Jason K. ^{[2
]}

Chuong, Michael D. ^{[3
]}

Regine, William F. ^{[1
]}

Kaiser, Adeel ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Dept Radiat Oncol, Baltimore, MD 21201 USA

[2] Univ Maryland, Med Ctr, Dept Radiat Oncol, Baltimore, MD 21201 USA

[3] Baptist Hlth South Florida, Miami Canc Inst, Dept Radiat Oncol, Miami, FL USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2017年 / 26卷 / 03期

关键词：

Pancreatic cancer; Pancreas cancer; Adjuvant; Neoadjuvant; Chemoradiation; Radiation therapy; Proton therapy; Stereotactic body radiotherapy; PHASE-II TRIAL; FULL-DOSE GEMCITABINE; INTENSITY-MODULATED RADIOTHERAPY; INTERFERON-BASED CHEMORADIATION; STEREOTACTIC BODY RADIOTHERAPY; CARBOHYDRATE ANTIGEN 19-9; TWICE-WEEKLY GEMCITABINE; NORMAL-TISSUE EXPOSURE; RESECTABLE ADENOCARCINOMA; CONCURRENT RADIATION;

D O I：

10.1016/j.soc.2017.01.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is the third leading cause of cancer-related death in the United States. Although surgery remains the only curative treatment, chemotherapy and radiation therapy are frequently used. In the adjuvant setting, radiation is usually delivered with chemotherapy to eradicate residual microscopic or macroscopic disease in the resection bed. Neoadjuvant radiation therapy has become more frequently utilized. This article reviews the historical and modern literature regarding radiation therapy in the neoadjuvant and adjuvant settings, focusing on the evolution of radiation therapy techniques and clinical trials in an attempt to identify patients best suited to receiving radiation therapy.

引用

页码：431 / +

页数：25

共 116 条

[21] Effect of neoadjuvant chemoradiation on operative mortality and morbidity for pancreaticoduodenectomy [J].

Cheng, TY ;

Sheth, K ;

White, RR ;

Ueno, T ;

Hung, CF ;

Clary, BM ;

Pappas, TN ;

Tyler, DS .

ANNALS OF SURGICAL ONCOLOGY, 2006, 13 (01) :66-74

[22] The expanding role of stereotactic body radiation therapy for pancreatic cancer: a review of the literature [J].

Chhabra, Arpit ;

Kaiser, Adeel ;

Regine, William F. ;

Chuong, Michael D. .

TRANSLATIONAL CANCER RESEARCH, 2015, 4 (06) :659-670

[23] A phase II study of adjuvant gemcitabine plus docetaxel followed by concurrent chemoradation in resected pancreaticobiliary carcinoma [J].

Cho, May ;

Wang-Gillam, Andrea ;

Myerson, Robert ;

Gao, Feng ;

Strasberg, Steven ;

Picus, Joel ;

Sorscher, Steven ;

Fournier, Chloe ;

Nagaraj, Gayathri ;

Parikh, Parag ;

Suresh, Rama ;

Linehan, David ;

Tan, Benjamin R. .

HPB, 2015, 17 (07) :587-593

[24] Adjuvant therapy for pancreatic cancer - The debate continues [J].

Choti, MA .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (12) :1249-1251

[25] Stereotactic Body Radiation Therapy for Locally Advanced and Borderline Resectable Pancreatic Cancer Is Effective and Well Tolerated [J].

Chuong, Michael D. ;

Springett, Gregory M. ;

Freilich, Jessica M. ;

Park, Catherine K. ;

Weber, Jill M. ;

Mellon, Eric A. ;

Hodul, Pamela J. ;

Malafa, Mokenge P. ;

Meredith, Kenneth L. ;

Hoffe, Sarah E. ;

Shridhar, Ravi .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2013, 86 (03) :516-522

[26] Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy [J].

Collisson, Eric A. ;

Sadanandam, Anguraj ;

Olson, Peter ;

Gibb, William J. ;

Truitt, Morgan ;

Gu, Shenda ;

Cooc, Janine ;

Weinkle, Jennifer ;

Kim, Grace E. ;

Jakkula, Lakshmi ;

Feiler, Heidi S. ;

Ko, Andrew H. ;

Olshen, Adam B. ;

Danenberg, Kathleen L. ;

Tempero, Margaret A. ;

Spellman, Paul T. ;

Hanahan, Douglas ;

Gray, Joe W. .

NATURE MEDICINE, 2011, 17 (04) :500-U140

[27] FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer [J].

Conroy, Thierry ;

Desseigne, Francoise ;

Ychou, Marc ;

Bouche, Olivier ;

Guimbaud, Rosine ;

Becouarn, Yves ;

Adenis, Antoine ;

Raoul, Jean-Luc ;

Gourgou-Bourgade, Sophie ;

de la Fouchardiere, Christelle ;

Bennouna, Jaafar ;

Bachet, Jean-Baptiste ;

Khemissa-Akouz, Faiza ;

Pere-Verge, Denis ;

Delbaldo, Catherine ;

Assenat, Eric ;

Chauffert, Bruno ;

Michel, Pierre ;

Montoto-Grillot, Christine ;

Ducreux, Michel .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (19) :1817-1825

[28] Adjuvant radiotherapy and chemotherapy for pancreatic carcinoma: The Mayo Clinic experience (1975-2005) [J].

Corsini, Michele M. ;

Miller, Robert C. ;

Haddock, Michael G. ;

Donohue, John H. ;

Farnell, Michael B. ;

Nagorney, David M. ;

Jatoi, Aminah ;

McWilliams, Robert R. ;

Kim, George P. ;

Bhatia, Sumita ;

Iott, Matthew J. ;

Gunderson, Leonard L. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (21) :3511-3516

[29]

Crane CH, 2004, NEW ENGL J MED, V350, P2713

[30] Phase II Trial of Cetuximab, Gemcitabine, and Oxaliplatin Followed by Chemoradiation With Cetuximab for Locally Advanced (T4) Pancreatic Adenocarcinoma: Correlation of Smad4(Dpc4) Immunostaining With Pattern of Disease Progression [J].

Crane, Christopher H. ;

Varadhachary, Gauri R. ;

Yordy, John S. ;

Staerkel, Gregg A. ;

Javle, Milind M. ;

Safran, Howard ;

Haque, Waqar ;

Hobbs, Bridgett D. ;

Krishnan, Sunil ;

Fleming, Jason B. ;

Das, Prajnan ;

Lee, Jeffrey E. ;

Abbruzzese, James L. ;

Wolff, Robert A. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (22) :3037-3043

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