Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit

被引：79
作者：
Ivanov, IP [1 ]
Gesteland, RF [1 ]
Atkins, JF [1 ]
机构：
[1] Univ Utah, Dept Human Genet, Salt Lake City, UT 84112 USA
来源：
NUCLEIC ACIDS RESEARCH | 2000年 / 28卷 / 17期
关键词：
D O I：
10.1093/nar/28.17.3185
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting.
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页码：3185 / 3196
页数：12
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