Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice

被引：20

作者：

Tanaka, Kazuhiro ^{[1
]}

Kunishige-Yamamoto, Akiko ^{[1
]}

Hashimoto, Hitoshi ^{[1
,2
,3
,4
]}

Shintani, Norihito ^{[1
]}

Hayata, Atsuko ^{[1
,2
]}

Baba, Akemichi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Mol Neuropharmacol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Suita, Osaka 5650871, Japan

[3] Kanazawa Univ, Osaka Univ, United Grad Sch Child Dev, Suita, Osaka 5650871, Japan

[4] Hamamatsu Univ Sch Med, Suita, Osaka 5650871, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 391卷 / 01期

基金：

日本学术振兴会;

关键词：

Ethanol; Hypothermia; PACAP; Reward; Sercionin 1A receptor; CYCLASE-ACTIVATING POLYPEPTIDE; ADENYLATE-CYCLASE; 8-OH-DPAT-INDUCED HYPOTHERMIA; INDUCED ANXIETY; ALCOHOL; HYPERACTIVITY; CONSUMPTION; INHIBITION; DROSOPHILA; BEHAVIORS;

D O I：

10.1016/j.bbrc.2009.11.136

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pituitary adenylate cyclase-activating polypeptide (PACAP)-deficient mice display remarkable behavioral changes including increased novelty-seeking behavior and reduced hypothermia Induced by either serotonin (5-HT)(1A) receptor agonists or ethanol Because 5-HT1A receptors have been implicated in the development of alcohol dependence. we have examined ethanol preference in PACAP-deficient Mice using a two-bottle choice and a conditioned place preference test. as well as additive effects of ethanol and 50HT(1A) receptor agents on hypothermia PACAP-deficient mice showed an increased preference towards ethanol compared with wild-type mice However. they showed no preference for the ethanol compartment after conditioning an neither preference nor aversion to Sucrose or quinine The 5-HT1A ieceptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) restored the attenuated hypothermic response to ethanol in the Mutants to similar levels in wild-type mice. with no effect in wild-types in contrast, the 5-HT1A receptor antagonist WAY-100635 attenuated the ethanol-induced hypothermia in wild-type mice. with no effect in the mutants. These results demonstrate increased ethanol preference in PACAP-deficient mice that may be mediated by 5-HT1A receptor-dependent attenuation of ethanol-induced central inhibition (C) 2009 Elsevier Inc All rights reserved

引用

页码：773 / 777

页数：5

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