Functional genomics and evolution of tick-Anaplasma interactions and vaccine development

被引：39

作者：

de la Fuente, Jose ^{[1
,2
]}

Kocan, Katherine M. ^{[1
]}

Blouin, Edmour F. ^{[1
]}

Zivkovic, Zorica ^{[3
]}

Naranjo, Victoria ^{[1
,2
]}

Almazan, Consuelo ^{[6
]}

Esteves, Eliane ^{[4
]}

Jongejan, Frans ^{[3
,5
]}

Daffre, Sirlei ^{[4
]}

Mangold, Atilio J. ^{[7
]}

机构：

[1] Oklahoma State Univ, Dept Vet Pathobiol, Ctr Vet Hlth Sci, Stillwater, OK 74078 USA

[2] CSIC UCLM JCCM, Inst Invest Recursos Cineget IREC, Ciudad Real 13005, Spain

[3] Univ Utrecht, Fac Vet Med, UCTD, Dept Immunol & Infect Dis, NL-3584 CL Utrecht, Netherlands

[4] Univ Sao Paulo, Dept Parasitol, Inst Ciencias Biomed, BR-05508900 Sao Paulo, Brazil

[5] Univ Pretoria, Fac Vet Sci, Dept Vet Trop Dis, ZA-0110 Onderstepoort, South Africa

[6] Univ Autonoma Tamaulipas, Fac Med Vet & Zootecn, Cd Victoria 87000, Tamaulipas, Mexico

[7] Inst Nacl Tecnol Agropecuaria, Estac Expt Agropecuaria Rafaela, RA-2300 Rafaela, Santa Fe, Argentina

来源：

VETERINARY PARASITOLOGY | 2010年 / 167卷 / 2-4期

关键词：

Anaplasma; Major surface protein; Genomics; RNA interference; Evolution; Vaccine; DERMACENTOR-ANDERSONI ACARI; OUTER-MEMBRANE PROTEINS; PROTECTIVE ANTIGEN SUBOLESIN; B-CELL EPITOPES; DIFFERENTIAL EXPRESSION; MARGINALE RICKETTSIALES; BOOPHILUS-MICROPLUS; HOST-CELLS; A-PHAGOCYTOPHILUM; GENETIC DIVERSITY;

D O I：

10.1016/j.vetpar.2009.09.019

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several tick-transmitted pathogens that impact veterinary and human health. Tick-borne pathogens cycle between tick vectors and vertebrate hosts and their interaction is mediated by molecular mechanisms at the tick-pathogen interface. These mechanisms have evolved characteristics that involve traits from both the tick vector and the pathogen to insure their mutual survival. Herein, we review the information obtained from functional genomics and genetic studies to characterize the tick-Anaplasma interface and evolution of A. marginale and A. phagocytophilum. Anaplasma and tick genes and proteins involved in tick-pathogen interactions were characterized. The results of these studies demonstrated that common and Anaplasma species-specific molecular mechanism occur by which pathogen and tick cell gene expression mediates or limits Anaplasma developmental cycle and trafficking through ticks. These results have advanced our understanding of the biology of tick-Anaplasma interactions and have opened new avenues for the development of improved methods for the control of tick infestations and the transmission of tick-borne pathogens. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：175 / 186

页数：12

共 107 条

[1] Anaplasma marginale major surface protein 2 CD4+-T-cell epitopes are evenly distributed in conserved and hypervariable regions (HVR), whereas linear B-cell epitopes are predominantly located in the HVR [J].

Abbott, JR ;

Palmer, GH ;

Howard, CJ ;

Hope, JC ;

Brown, WC .

INFECTION AND IMMUNITY, 2004, 72 (12) :7360-7366

[2] Rapid and long-term disappearance of CD4+ T lymphocyte responses specific for Anaplasma marginale major surface protein-2 (MSP2) in MSP2 vaccinates following challenge with live A-marginale [J].

Abbott, JR ;

Palmer, GH ;

Kegerreis, KA ;

Hetrick, PF ;

Howard, CJ ;

Hope, JC ;

Brown, WC .

JOURNAL OF IMMUNOLOGY, 2005, 174 (11) :6702-6715

[3] Genetic diversity of Anaplasma marginale strains from an outbreak of bovine anaplasmosis in an endemic area [J].

Alamzan, Consuelo ;

Medrano, Citlaly ;

Ortiz, Martin ;

de la Fuente, Jose .

VETERINARY PARASITOLOGY, 2008, 158 (1-2) :103-109

[4] MOLECULAR-BASIS FOR SURFACE-ANTIGEN SIZE POLYMORPHISMS AND CONSERVATION OF A NEUTRALIZATION-SENSITIVE EPITOPE IN ANAPLASMA-MARGINALE [J].

ALLRED, DR ;

MCGUIRE, TC ;

PALMER, GH ;

LEIB, SR ;

HARKINS, TM ;

MCELWAIN, TF ;

BARBET, AF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3220-3224

[5] Vaccination with recombinant tick antigens for the control of Ixodes scapularis adult infestations [J].

Almazán, C ;

Kocan, KM ;

Blouin, EE ;

de la Fuente, J .

VACCINE, 2005, 23 (46-47) :5294-5298

[6] Characterization of three Ixodes scapularis cDNAs protective against tick infestations [J].

Almazán, C ;

Blas-Machado, U ;

Kocan, KM ;

Yoshioka, JH ;

Blouin, EF ;

Mangold, AJ ;

de la Fuente, J .

VACCINE, 2005, 23 (35) :4403-4416

[7] Identification of protective antigens for the control of Ixodes scapularis infestations using cDNA expression library immunization [J].

Almazán, C ;

Kocan, KM ;

Bergman, DK ;

Garcia-Garcia, JC ;

Blouin, EF ;

de la Fuente, J .

VACCINE, 2003, 21 (13-14) :1492-1501

[8] Genetic diversity of Anaplasma marginale strains from an outbreak of bovine anaplasmosis in an endemic area (vol 158, pg 103, 2008) [J].

Almazan, Consuelo ;

Medrano, Citlaly ;

Ortiz, Martin ;

de la Fuente, Jose .

VETERINARY PARASITOLOGY, 2009, 160 (3-4) :362-362

[9] Tick cell lines: tools for tick and tick-borne disease research [J].

Bell-Sakyi, Lesley ;

Zweygarth, Erich ;

Blouin, Edmour F. ;

Gould, Ernest A. ;

Jongejan, Frans .

TRENDS IN PARASITOLOGY, 2007, 23 (09) :450-457

[10]

Blouin Edmour F., 2002, Animal Health Research Reviews, V3, P57, DOI 10.1079/AHRR200241

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