Development and Characterization of a Sucrose Microneedle Neural Electrode Delivery System

被引:31
作者
Apollo, Nicholas V. [1 ,2 ]
Jiang, Jonathan [3 ]
Cheung, Warwick [3 ]
Baquier, Sebastien [3 ,4 ]
Lai, Alan [3 ]
Mirebedini, Azadeh [5 ]
Foroughi, Javad [5 ]
Wallace, Gordon G. [5 ]
Shivdasani, Mohit N. [2 ,6 ]
Prawer, Steven [1 ]
Chen, Shou [7 ]
Williams, Richard [7 ,8 ]
Cook, Mark J. [3 ]
Nayagam, David A. X. [2 ,8 ]
Garrett, David J. [1 ,2 ]
机构
[1] Univ Melbourne, Sch Phys, Parkville, Vic 3010, Australia
[2] Bion Inst, 384-388 Albert St, East Melbourne, Vic 3002, Australia
[3] Univ Melbourne, Dept Med, Parkville, Vic 3010, Australia
[4] Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic 3010, Australia
[5] Univ Wollongong, AIIM Facil, IPRI, Innovat Campus, Wollongong, NSW 2522, Australia
[6] Univ Melbourne, Dept Med Bion, Parkville, Vic 3010, Australia
[7] St Vincents Hosp Melbourne, Dept Anat Pathol, Fitzroy, Vic 3065, Australia
[8] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
brain-machine interfaces; carbon nanotubes; electrophysiology; graphene; water-soluble microneedles; BRAIN-TISSUE; NEEDLE INSERTION; STIMULATION; TEMPERATURE; FABRICATION; INTERFACES; SEIZURE; DRUG; PAIN; SOFT;
D O I
10.1002/adbi.201700187
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Stable brain-machine interfaces present extraordinary therapeutic and scientific promise. However, the electrode-tissue interface is susceptible to instability and damage during long-term implantation. Soft, flexible electrodes demonstrate improved longevity, but pose a new challenge with regard to simple and accurate surgical implantation. A high aspect ratio water-soluble microneedle is developed based on sucrose which permits straightforward surgical implantation of soft, flexible microelectrodes. Here, a description of the microneedle manufacturing process is presented, along with in vitro and in vivo safety and efficacy assessments. Successful fabrication requires control of the glass transition temperature of aqueous sucrose solutions. The insertion force of 5 different microneedle electrode vehicles is studied in agarose brain phantoms, with the sucrose microneedle eliciting the lowest insertion force and strain energy transfer. Short- and long-term assessments of the pathological response to sucrose microneedle implantations in the brain suggest minimal tissue reactions, comparable to those observed following stainless-steel hypodermic needle punctures. Finally, microelectrodes fabricated from graphene, carbon nanotubes, or platinum are embedded in sucrose microneedles and implanted into an epileptic rat model for 22 d. All electrodes are functional throughout the implantation period, with the graphene electrode exhibiting the largest seizure signal-to-noise ratio and only modest changes in impedance.
引用
收藏
页数:11
相关论文
共 71 条
[1]  
Agorelius J, 2015, FRONT NEUROSCI-SWITZ, V9, DOI [10.3389/fnins.7015.00331, 10.3389/fnins.2015.00331]
[2]   Needle insertion and radioactive seed implantation in human tissues: Simulation and sensitivity analysis [J].
Alterovitz, R ;
Goldberg, K ;
Pouliot, J ;
Taschereau, R ;
Hsu, IC .
2003 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION, VOLS 1-3, PROCEEDINGS, 2003, :1793-1799
[3]  
[Anonymous], 2009, HDB BIOL STAT
[4]   Soft, Flexible Freestanding Neural Stimulation and Recording Electrodes Fabricated from Reduced Graphene Oxide [J].
Apollo, Nicholas V. ;
Maturana, Matias I. ;
Tong, Wei ;
Nayagam, David A. X. ;
Shivdasani, Mohit N. ;
Foroughi, Javad ;
Wallace, Gordon G. ;
Prawer, Steven ;
Ibbotson, Michael R. ;
Garrett, David J. .
ADVANCED FUNCTIONAL MATERIALS, 2015, 25 (23) :3551-3559
[5]   First-in-Human Trial of a Novel Suprachoroidal Retinal Prosthesis [J].
Ayton, Lauren N. ;
Blamey, Peter J. ;
Guymer, Robyn H. ;
Luu, Chi D. ;
Nayagam, David A. X. ;
Sinclair, Nicholas C. ;
Shivdasani, Mohit N. ;
Yeoh, Jonathan ;
McCombe, Mark F. ;
Briggs, Robert J. ;
Opie, Nicholas L. ;
Villalobos, Joel ;
Dimitrov, Peter N. ;
Varsamidis, Mary ;
Petoe, Matthew A. ;
McCarthy, Chris D. ;
Walker, Janine G. ;
Barnes, Nick ;
Burkitt, Anthony N. ;
Williams, Chris E. ;
Shepherd, Robert K. ;
Allen, Penelope J. .
PLOS ONE, 2014, 9 (12)
[6]   Fracture Mechanics Model of Needle Cutting Tissue [J].
Barnett, Andrew C. ;
Lee, Yuan-Shin ;
Moore, Jason Z. .
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME, 2016, 138 (01)
[7]   Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates [J].
Barrese, James C. ;
Rao, Naveen ;
Paroo, Kaivon ;
Triebwasser, Corey ;
Vargas-Irwin, Carlos ;
Franquemont, Lachlan ;
Donoghue, John P. .
JOURNAL OF NEURAL ENGINEERING, 2013, 10 (06)
[8]   The brain tissue response to implanted silicon microelectrode arrays is increased when the device is tethered to the skull [J].
Biran, Roy ;
Martin, Dave C. ;
Tresco, Patrick A. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2007, 82A (01) :169-178
[9]   Effect of Needle Insertion Speed on Tissue Injury, Stress, and Backflow Distribution for Convection-Enhanced Delivery in the Rat Brain [J].
Casanova, Fernando ;
Carney, Paul R. ;
Sarntinoranont, Malisa .
PLOS ONE, 2014, 9 (04)
[10]   In vivo evaluation of needle force and friction stress during insertion at varying insertion speed into the brain [J].
Casanova, Fernando ;
Carney, Paul R. ;
Sarntinoranont, Malisa .
JOURNAL OF NEUROSCIENCE METHODS, 2014, 237 :79-89