Serum levels of soluble intercellular adhesion molecule-1 and soluble endothelial leukocyte adhesion molecule-1 in Alzheimer's disease

被引：39
作者：
Rentzos, A
Michalopoulou, M
Nikolaou, C
Cambouri, C
Rombos, A
Dimitrakopoulos, A
Kapaki, E
Vassilopoulos, D
机构：
[1] Aeginit Hosp, Dept Neurol, Athens Med Sch, Athens 11528, Greece
[2] Aeginit Hosp, Dept Biopathol Neuroimmunol, Athens Med Sch, Athens 11528, Greece
来源：
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY | 2004年 / 17卷 / 04期
关键词：
ICAM-1; ELAM-1; Alzheimer's disease; immunological processes;
D O I：
10.1177/0891988704269822
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Serum soluble intercellular adhesion molecule-1 (s-ICAM-1) and soluble E-selectin (s-ELAM-1) were evaluated in 25 patients with Alzheimer's disease (AD), 54 patients with noninflammatory neurological diseases (NIND), and 15 control subjects. Patients with AD had a higher s-ICAM-1 level compared with the NIND patients and the control subjects (P <.001 and P <.04, respectively). The presence of high s-ICAM-1 values may be related to immunological processes involved in pathogenetic mechanisms of AD. The not statistically significant values of (s-ELAM-1), a glycoprotein considered an exclusive marker of endothelial activation, compared with the NIND patients and healthy subjects (P <.47 and P <.17, respectively), seem to suggest the neural rather than the endothelial s-ICAM origin in patients with AD.
引用
收藏
页码：225 / 231
页数：7
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