Serum levels of soluble intercellular adhesion molecule-1 and soluble endothelial leukocyte adhesion molecule-1 in Alzheimer's disease

被引：39

作者：

Rentzos, A

Michalopoulou, M

Nikolaou, C

Cambouri, C

Rombos, A

Dimitrakopoulos, A

Kapaki, E

Vassilopoulos, D

机构：

[1] Aeginit Hosp, Dept Neurol, Athens Med Sch, Athens 11528, Greece

[2] Aeginit Hosp, Dept Biopathol Neuroimmunol, Athens Med Sch, Athens 11528, Greece

来源：

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY | 2004年 / 17卷 / 04期

关键词：

ICAM-1; ELAM-1; Alzheimer's disease; immunological processes;

D O I：

10.1177/0891988704269822

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Serum soluble intercellular adhesion molecule-1 (s-ICAM-1) and soluble E-selectin (s-ELAM-1) were evaluated in 25 patients with Alzheimer's disease (AD), 54 patients with noninflammatory neurological diseases (NIND), and 15 control subjects. Patients with AD had a higher s-ICAM-1 level compared with the NIND patients and the control subjects (P <.001 and P <.04, respectively). The presence of high s-ICAM-1 values may be related to immunological processes involved in pathogenetic mechanisms of AD. The not statistically significant values of (s-ELAM-1), a glycoprotein considered an exclusive marker of endothelial activation, compared with the NIND patients and healthy subjects (P <.47 and P <.17, respectively), seem to suggest the neural rather than the endothelial s-ICAM origin in patients with AD.

引用

页码：225 / 231

页数：7

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