Tuning the properties of porous chitosan: Aerogels and cryogels

被引：71

作者：

Chartier, Coraline ^{[1
]}

Buwalda, Sytze ^{[1
]}

Van Den Berghe, Helene ^{[2
]}

Nottelet, Benjamin ^{[2
]}

Budtova, Tatiana ^{[1
]}

机构：

[1] PSL Res Univ, Ctr Mat Forming CEMEF, MINES ParisTech, UMR CNRS 7635, CS 10207, F-06904 Sophia Antipolis, France

[2] Univ Montpellier, Dept Polymers Hlth & Biomat, IBMM, CNRS,ENSCM, Montpellier, France

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2022年 / 202卷

关键词：

Density; Specific surface area; Porosity; Freeze-drying; Supercritical drying; FABRICATION; SCAFFOLDS; CELLULOSE; CHITIN;

D O I：

10.1016/j.ijbiomac.2022.01.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Highly porous chitosan-based materials were prepared via dissolution, non-solvent induced phase separation and drying using different methods. The goal was to tune the morphology and properties of chitosan porous materials by varying process parameters. Chitosan concentration, concentration of sodium hydroxide in the coagulation bath and aging time were varied. Drying was performed via freeze-drying leading to "cryogels " or via drying with supercritical CO2 leading to "aerogels ". Cryogels were of lower density than aerogels (0.03-0.12 g/cm(3) vs 0.07-0.26 g/cm(3), respectively) and had a lower specific surface area (50-70 vs 200-270 m(2)/g, respectively). The absorption of simulated wound exudate by chitosan aerogels and cryogels was studied in view of their potential applications as wound dressing. Higher absorption was obtained for cryogels (530-1500%) as compared to aerogels (200-610%).

引用

页码：215 / 223

页数：9

共 45 条

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