Curcumin-loaded silica-based mesoporous materials: Synthesis, characterization and cytotoxic properties against cancer cells

被引:77
作者
Bollu, Vishnu Sravan [1 ,4 ]
Barui, Ayan Kumar [1 ,4 ]
Mondal, Sujan Kumar [1 ,4 ]
Prashar, Sanjiv [2 ]
Fajardo, Mariano [2 ]
Briones, David [3 ]
Rodriguez-Dieguez, Antonio [3 ]
Patra, Chitta Ranjan [1 ,4 ]
Gomez-Ruiz, Santiago [2 ]
机构
[1] CSIR Indian Inst Chem Technol, Biomat Grp, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India
[2] Univ Rey Juan Carlos, Dept Biol & Geol Fis & Quim Inorgan, ESCET, Calle Tulipan S-N, Madrid 28933, Spain
[3] Univ Granada, Fac Ciencias, Dept Quim Inorgan, Fuente Nueva S-N, E-18071 Granada, Spain
[4] Acad Sci & Innovat Res AcSIR, Madras 600113, Tamil Nadu, India
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 63卷
关键词
Mesoporous silica materials; Cytotoxicity; Anti-cancer; Curcumin; Nanomedicine; DRUG-DELIVERY SYSTEM; ANTICANCER APPLICATIONS; CONTROLLED-RELEASE; NANOPARTICLES; APOPTOSIS; THERAPY; BIOCOMPATIBILITY; BIODISTRIBUTION; BIOAVAILABILITY; ABSORPTION;
D O I
10.1016/j.msec.2016.03.011
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Two different silica based (MSU-2 and MCM-41) curcumin loaded mesoporous materials V3 and V6 were synthesized and characterized by several physico-chemical techniques. Release kinetic study revealed the slow and sustained release of curcumin from those materials in blood simulated fluid (pH: 7.4). The materials V3 and V6 were found to be biocompatible in non-cancerous CHO cell line while exhibiting significant cytotoxicity in different cancer cells (human lung carcinoma cells: A549, human breast cancer cells: MCF-7, mouse melanoma cells: B16F10) compared to pristine curcumin indicating the efficacy of the mesoporous silica materials based drug delivery systems (DDSs). The generation of intracellular reactive oxygen species (ROS) and down regulation of anti-apoptotic protein leading to the induction of apoptosis were found to be the plausible mechanisms behind the anti-cancer activity of these DDSs. These results suggest that curcumin-loaded drug delivery system may be successfully employed as an alternative treatment strategy for cancer therapeutics through a nanomedicine approach in near future. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:393 / 410
页数:18
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