Two different silica based (MSU-2 and MCM-41) curcumin loaded mesoporous materials V3 and V6 were synthesized and characterized by several physico-chemical techniques. Release kinetic study revealed the slow and sustained release of curcumin from those materials in blood simulated fluid (pH: 7.4). The materials V3 and V6 were found to be biocompatible in non-cancerous CHO cell line while exhibiting significant cytotoxicity in different cancer cells (human lung carcinoma cells: A549, human breast cancer cells: MCF-7, mouse melanoma cells: B16F10) compared to pristine curcumin indicating the efficacy of the mesoporous silica materials based drug delivery systems (DDSs). The generation of intracellular reactive oxygen species (ROS) and down regulation of anti-apoptotic protein leading to the induction of apoptosis were found to be the plausible mechanisms behind the anti-cancer activity of these DDSs. These results suggest that curcumin-loaded drug delivery system may be successfully employed as an alternative treatment strategy for cancer therapeutics through a nanomedicine approach in near future. (C) 2016 Elsevier B.V. All rights reserved.
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King Abdulaziz Univ, Fac Sci, Dept Phys, Med Phys Program, Jeddah 21589, Saudi Arabia
Cairo Univ, Fac Sci, Dept Biophys, Giza 12613, EgyptKing Abdulaziz Univ, Fac Sci, Dept Phys, Med Phys Program, Jeddah 21589, Saudi Arabia
Elbialy, Nihal S.
Aboushoushah, Samia Faisal
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King Abdulaziz Univ, Fac Sci, Dept Phys, Med Phys Program, Jeddah 21589, Saudi ArabiaKing Abdulaziz Univ, Fac Sci, Dept Phys, Med Phys Program, Jeddah 21589, Saudi Arabia
Aboushoushah, Samia Faisal
Sofi, Balsam Fahad
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King Abdulaziz Univ, Fac Sci, Dept Phys, Med Phys Program, Jeddah 21589, Saudi Arabia
Umm Al Qura Univ, Med Phys, Dept Phys, Coll Appl Sci, Mecca, Saudi ArabiaKing Abdulaziz Univ, Fac Sci, Dept Phys, Med Phys Program, Jeddah 21589, Saudi Arabia
Sofi, Balsam Fahad
Noorwali, Abdulwahab
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King Abdulaziz Univ, Sch Med, Jeddah, Saudi ArabiaKing Abdulaziz Univ, Fac Sci, Dept Phys, Med Phys Program, Jeddah 21589, Saudi Arabia