Sarcomas

被引：53
作者：
HaDuong, Josephine H. [1 ]
Martin, Andrew A. [2 ]
Skapek, Stephen X. [2 ]
Mascarenhas, Leo [1 ]
机构：
[1] Univ So Calif, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Dept Pediat,Childrens Ctr Canc & Blood Dis,Keck S, Los Angeles, CA 90027 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Pediat, Pauline Allen Gill Ctr Canc & Blood Disorders, Div Hematol Oncol,Childrens Med Ctr, Dallas, TX 75390 USA
来源：
PEDIATRIC CLINICS OF NORTH AMERICA | 2015年 / 62卷 / 01期
关键词：
Soft-tissue sarcoma; Rhabdomyosarcoma; Nonrhabdomyosarcoma; Bone; Ewing's; Osteosarcoma; PRIMITIVE NEUROECTODERMAL TUMOR; NONMETASTATIC EWINGS-SARCOMA; HIGH-GRADE OSTEOSARCOMA; SOFT-TISSUE SARCOMAS; PROGNOSTIC-FACTORS; NEOADJUVANT CHEMOTHERAPY; ALVEOLAR RHABDOMYOSARCOMA; SINGLE INSTITUTION; MOLECULAR-BIOLOGY; FAMILY TUMORS;
D O I：
10.1016/j.pcl.2014.09.012
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Malignant bone tumors (osteosarcoma, Ewing sarcoma) and soft-tissue sarcomas (rhabdomyosarcoma, nonrhabdomyosarcoma) account for approximately 14% of childhood malignancies. Successful treatment of patients with sarcoma depends on a multidisciplinary approach to therapy, including oncology, surgery, radiation oncology, radiology, pathology, and physiatry. By combining systemic treatment with chemotherapy and primary tumor control using surgery and/or radiation, survival rates for localized disease range from 70% to 75%. However, children with metastatic or recurrent disease continue to have dismal outcomes. A better understanding of the biology underlying both bone and soft-tissue sarcomas is required to further improve outcomes for children with these tumors.
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收藏
页码：179 / +
页数：23
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