Accounting for the genetic load in assisted reproductive technology

被引：4
作者：
van Oosterhout, Cock [1 ]
Marcu, Daniel [2 ]
Immler, Simone [2 ]
机构：
[1] Univ East Anglia, Sch Environm Sci, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England
[2] Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England
来源：
CLINICAL AND TRANSLATIONAL MEDICINE | 2022年 / 12卷 / 05期
基金：
英国生物技术与生命科学研究理事会; 欧洲研究理事会;
关键词：
assisted reproductive technology; deleterious mutations; genetic load; human fertility; TERM HEALTH OUTCOMES; CHILDREN BORN; CONSEQUENCES; MUTATIONS; FITNESS;
D O I：
10.1002/ctm2.864
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The genetic load in the human genome has important ramifications for assisted reproductive technology (ART), human reproduction and fertility more generally. Here, we discuss these topics in the light of evolutionary genetic theory, the technological revolution in ART and the advances in the fields of genomics and bioinformatics.
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页数：4
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