Nanostructure-based surface-enhanced Raman scattering biosensors for nucleic acids and proteins

被引:86
作者
Chao, Jie [1 ,2 ]
Cao, Wenfang [1 ,2 ]
Su, Shao [1 ,2 ]
Weng, Lixing [3 ]
Song, Shiping [4 ]
Fan, Chunhai [4 ]
Wang, Lianhui [1 ,2 ]
机构
[1] Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, IAM, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China
[3] Nanjing Univ Posts & Telecommun, Coll Geog & Biol Informat, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China
基金
中国国家自然科学基金;
关键词
ROLLING-CIRCLE AMPLIFICATION; LABEL-FREE DETECTION; SERS HOT-SPOTS; SEQUENCE-SPECIFIC DETECTION; PROSTATE-SPECIFIC ANTIGEN; MULTIPLEXED DNA DETECTION; VIVO CANCER-DETECTION; GOLD NANOPARTICLES; HIGH-SENSITIVITY; ULTRASENSITIVE DETECTION;
D O I
10.1039/c5tb02135a
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Detection of nucleic acid and protein targets related to human health and safety has attracted widespread attention. Surface-enhanced Raman scattering (SERS) is a powerful tool for biomarker detection because of its ultrahigh detection sensitivity and unique fingerprinting spectra. In this review, we first introduce the development of nanostructure-based SERS-active substrates and SERS nanotags, which greatly influence the performance of SERS biosensors. We then focus on recent advances in SERS biosensors for DNA, microRNA and protein determination, including label-free, labeled and multiplex analyses as well as in vivo imaging. Finally, the prospects and challenges of such nanostructure-based SERS biosensors are discussed.
引用
收藏
页码:1757 / 1769
页数:13
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