Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant

被引：57

作者：

Ishii, I. ^{[1
]}

Mizuta, H. ^{[1
]}

Sei, A. ^{[1
]}

Hirose, J. ^{[1
]}

Kudo, S. ^{[1
]}

Hiraki, Y. ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Med & Pharmaceut Sci, Dept Orthopaed & Neuromusculoskeletal Surg, Kumamoto 8608556, Japan

来源：

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME | 2007年 / 89B卷 / 05期

关键词：

D O I：

10.1302/0301-620X.89B5.18450

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

We have investigated in vitro the release kinetics and bioactivity of fibroblast growth factor-2 (FGF-2) released from a carrier of fibrin sealant. In order to evaluate the effects of the FGF-2 delivery mechanism on the repair of articular cartilage, full-thickness cylindrical defects, 5 mm in diameter and 4 mm in depth, which were too large to undergo spontaneous repair, were created in the femoral trochlea of rabbit knees. These defects were then filled with the sealant. Approximately 50% of the FGF-2 was released from the sealant within 24 hours while its original bioactivity was maintained. The implantation of the fibrin sealant incorporating FGF-2 successfully induced healing of the surface with hyaline cartilage and concomitant repair of the subchondral bone at eight weeks after the creation of the defect. Our findings suggest that this delivery method for FGF-2 may be useful for promoting regenerative repair of full-thickness defects of articular cartilage in humans.

引用

页码：693 / 700

页数：8

共 38 条

[1] MENISCAL REPAIR USING AN EXOGENOUS FIBRIN CLOT - AN EXPERIMENTAL-STUDY IN DOGS [J].