Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China

被引：146

作者：

Ke, Changwen ^{[1
]}

Mok, Chris Ka Pun ^{[2
,3
]}

Zhu, Wenfei ^{[4
]}

Zhou, Haibo ^{[5
]}

He, Jianfeng ^{[1
]}

Guan, Wenda ^{[2
]}

Wu, Jie ^{[1
]}

Song, Wenjun ^{[6
]}

Wang, Dayan ^{[4
]}

Liu, Jiexiong ^{[5
]}

Lin, Qinhan ^{[5
]}

Chu, Daniel Ka Wing ^{[3
]}

Yang, Lei ^{[4
]}

Zhong, Nanshan ^{[2
,7
]}

Yang, Zifeng ^{[2
,7
]}

Shu, Yuelong ^{[4
]}

Peiris, Joseph Sriyal Malik ^{[2
,3
]}

机构：

[1] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China

[2] Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China

[3] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China

[4] China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China

[5] Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan, Peoples R China

[6] Jinan Univ, Guangzhou, Guangdong, Peoples R China

[7] Macau Univ Sci & Technol, Macau, Peoples R China

来源：

EMERGING INFECTIOUS DISEASES | 2017年 / 23卷 / 08期

基金：

中国国家自然科学基金;

关键词：

A H7N9 VIRUS; MULTIBASIC CLEAVAGE SITE; MAMMALIAN HOSTS; H5N1; VIRUS; HEMAGGLUTININ; SUBSTITUTIONS; GUANGZHOU; VIRULENCE; FERRETS; PROTEIN;

D O I：

10.3201/eid2308.170600

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recent increase in zoonotic avian influenza A(H7N9) disease in China is a cause of public health concern. Most of the A(H7N9) viruses previously reported have been of low pathogenicity. We report the fatal case of a patient in China who was infected with an A(H7N9) virus having a polybasic amino acid sequence at its hemagglutinin cleavage site (PEVPKRKRTAR/GL), a sequence suggestive of high pathogenicity in birds. Its neuraminidase also had R292K, an amino acid change known to be associated with neuraminidase inhibitor resistance. Both of these molecular features might have contributed to the patient's adverse clinical outcome. The patient had a history of exposure to sick and dying poultry, and his close contacts had no evidence of A(H7N9) disease, suggesting human-to-human transmission did not occur. Enhanced surveillance is needed to determine whether this highly pathogenic avian influenza A(H7N9) virus will continue to spread.

引用

页码：1332 / 1340

页数：9

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