Duplex DNA as a self-assembling template for the identification of bidentate protein-binding agents

被引：8
作者：
Tagore, Debarati M.
Sprinz, K. Ingrid
Hamilton, Andrew D.
机构：
[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA
[2] Yale Univ, Dept Biochem & Mol Biophys, New Haven, CT 06520 USA
来源：
SUPRAMOLECULAR CHEMISTRY | 2007年 / 19卷 / 1-2期
关键词：
duplex DNA; bidentate; self-assembly;
D O I：
10.1080/10610270600990253
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This paper reviews the versatile self-assembly of bidentate protein-binding agents on a duplex DNA scaffold, as demonstrated using the biotin-streptavidin system. The preferential binding and stabilization of bidentate biotin-containing duplexes is reflected in a 128 degrees C increase in the melting temperature of the duplex in the presence of streptavidin.
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收藏
页码：129 / 136
页数：8
相关论文
共 72 条
[1]   Duplex oligomers defined via covalent casting of a one-dimensional hydrogen-bonding motif [J].
Archer, EA ;
Krische, MJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (18) :5074-5083
[2]   Generation of an equilibrating collection of circular inorganic copper(I) architectures and solid-state stabilisation of the dicopper helicate component [J].
Baxter, PNW ;
Lehn, JM ;
Rissanen, K .
CHEMICAL COMMUNICATIONS, 1997, (14) :1323-1324
[3]   Small-molecule diversification from iterated branching reaction pathways enabled by DNA-templated synthesis [J].
Calderone, CT ;
Liu, DR .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (45) :7383-7386
[4]   Covalent capture of dynamic hydrogen-bonded assemblies [J].
Cardullo, F ;
Calama, MC ;
Snellink-Ruël, BHM ;
Weidmann, JL ;
Bielejewska, A ;
Fokkens, R ;
Nibbering, NMM ;
Timmerman, P ;
Reinhoudt, DN .
CHEMICAL COMMUNICATIONS, 2000, (05) :367-368
[5]   Antagonists of protein-protein interactions [J].
Cochran, AG .
CHEMISTRY & BIOLOGY, 2000, 7 (04) :R85-R94
[6]   Self-assembling capsules [J].
Conn, MM ;
Rebek, J .
CHEMICAL REVIEWS, 1997, 97 (05) :1647-1668
[7]   Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine [J].
Cwirla, SE ;
Balasubramanian, P ;
Duffin, DJ ;
Wagstrom, CR ;
Gates, CM ;
Singer, SC ;
Davis, AM ;
Tansik, RL ;
Mattheakis, LC ;
Boytos, CM ;
Schatz, PJ ;
Baccanari, DP ;
Wrighton, NC ;
Barrett, RW ;
Dower, WJ .
SCIENCE, 1997, 276 (5319) :1696-1699
[8]  
DAVIES DR, 1990, ANNU REV BIOCHEM, V59, P439, DOI 10.1146/annurev.biochem.59.1.439
[9]   5′-Tethered stilbene derivatives as fidelity- and affinity-enhancing modulators of DNA duplex stability [J].
Dogan, Z ;
Paulini, R ;
Stütz, JAR ;
Narayanan, S ;
Richert, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (15) :4762-4763
[10]   Making drugs on proteins: site-directed ligand discovery for fragment-based lead assembly [J].
Erlanson, DA ;
Hansen, SK .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2004, 8 (04) :399-406
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