Genomics of Brain Tumor Imaging

被引：26

作者：

Pope, Whitney B. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, Los Angeles, CA 90095 USA

来源：

NEUROIMAGING CLINICS OF NORTH AMERICA | 2015年 / 25卷 / 01期

关键词：

Imaging genomics; Radiogenomics; Glioblastoma; Microarray; Glioma; Bioinformatics; MESSENGER-RNA EXPRESSION; GLIOBLASTOMA-MULTIFORME; GENE-EXPRESSION; GROWTH-FACTOR; MOLECULAR CLASSIFICATION; MICROARRAY ANALYSIS; SURVIVAL; PHENOTYPE; CANCER; EDEMA;

D O I：

10.1016/j.nic.2014.09.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Imaging genomics combines imaging-defined phenotypes with molecular determinants of disease. Recent studies have examined the relationship between MRI-derived feature sets and gene expression in gliomas, including glioblastoma (GBM). Several groups have identified correlations between the expression of particular molecularly defined oncogenic pathways in GBM and malignant phenotypes on MRI. The combination of clinical, genetic, and imaging data has improved prognostic modeling and has identified potential therapeutic targets. Many challenges remain in fully leveraging the associations between such large datasets, but even current methodology shows promise in helping to craft individually tailored treatments to patients with brain tumors and other diseases.

引用

页码：105 / +

页数：17

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