Senescence in Health and Disease

被引：1337

作者：

He, Shenghui ^{[1
,2
,3
]}

Sharpless, Norman E. ^{[1
,2
,3
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

CELL | 2017年 / 169卷 / 06期

关键词：

DNA-DAMAGE RESPONSE; HEMATOPOIETIC STEM-CELLS; PANCREATIC BETA-CELLS; CELLULAR SENESCENCE; SECRETORY PHENOTYPE; TUMOR SUPPRESSION; IN-VIVO; ANTIVIRAL DEFENSE; CANCER RESISTANCE; FAMILY-MEMBERS;

D O I：

10.1016/j.cell.2017.05.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many cellular stresses activate senescence, a persistent hyporeplicative state characterized in part by expression of the p16(INK4a) cell-cycle inhibitor. Senescent cell production occurs throughout life and plays beneficial roles in a variety of physiological and pathological processes including embryogenesis, wound healing, host immunity, and tumor suppression. Meanwhile, the steady accumulation of senescent cells with age also has adverse consequences. These non-proliferating cells occupy key cellular niches and elaborate pro-inflammatory cytokines, contributing to aging-related diseases and morbidity. This model suggests that the abundance of senescent cells in vivo predicts "molecular," as opposed to chronologic, age and that senescent cell clearance may mitigate aging-associated pathology.

引用

页码：1000 / 1011

页数：12

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