ω-Ethylenic Allylic Substrates as Alternatives to Cyclic Substrates in Copper- and Iridium-Catalyzed Asymmetric Allylic Alkylation

被引：28

作者：

Giacomina, Francesca ^{[1
]}

Riat, David ^{[1
]}

Alexakis, Alexandre ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

CONJUGATE ADDITION; LIGANDS; OLEFINS;

D O I：

10.1021/ol100162y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy to access highly enantioenriched cyclic compounds (up to 98%) is proposed using omega-ethylenic allylic substrates through a one-pot asymmetric allylic alkylation and ring-closing metathesis. Such starting compounds can be seen as synthetic equivalents of cyclic allylic substrates.

引用

页码：1156 / 1159

页数：4

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