Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer

被引：1

作者：

Zhang, Y. ^{[1
]}

Chen, Q. ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Nanchang, Jiangxi, Peoples R China

来源：

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 2017年 / 50卷 / 06期

基金：

美国国家科学基金会;

关键词：

Ovarian cancer; Matrix metalloproteinases (MMPs); Tissue inhibitor of metalloproteinases (TIMPs); Invasion; Metastasis; TUMOR-GROWTH; TISSUE INHIBITORS; CARCINOMA CELLS; EXPRESSION; INVASION; MMP-7; PROLIFERATION; METAANALYSIS; METASTASIS; PROGNOSIS;

D O I：

10.1590/1414-431X20176104

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to be related to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discovered that the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignant phenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation of MMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survival rate of patients with ovarian cancer.

引用

页数：8

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