Impaired Awareness of Deficits and Neuropsychiatric Symptoms in Early Alzheimer's Disease: The Danish Alzheimer Intervention Study (DAISY)

被引：31

作者：

Vogel, Asmus ^{[1
]}

Waldorff, Frans Boch ^{[1
,2
,3
]}

Waldemar, Gunhild ^{[1
]}

机构：

[1] Rigshosp, Copenhagen Univ Hosp, Ctr Neurosci, Memory Disorders Res Grp,Dept Neurol,Sect 6702, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Res Unit, DK-1168 Copenhagen, Denmark

[3] Univ Copenhagen, Dept Gen Practice, DK-1168 Copenhagen, Denmark

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2010年 / 22卷 / 01期

关键词：

MILD COGNITIVE IMPAIRMENT; ANOSOGNOSIA; DEMENTIA; INSIGHT; DEPRESSION; APATHY; INVENTORY;

D O I：

10.1176/appi.neuropsych.22.1.93

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Impaired awareness may be associated with increased neuropsychiatric symptoms in moderate to severe Alzheimer's disease, but relatively little is known about the association in early Alzheimer's disease. The aim of this study was to investigate if impaired awareness was associated with a higher frequency of neuropsychiatric symptoms in early Alzheimer's disease. In a Danish multicenter study, 321 patients with MMSE score >= 20 were evaluated. Patients with poor insight had significantly more neuropsychiatric symptoms than patients with full insight. When patients had increasing neuropsychiatric symptoms, caregivers reported higher levels of distress. (The Journal of Neuropsychiatry and Clinical Neurosciences 2010; 22:93-99)

引用

页码：93 / 99

页数：7

共 24 条

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