Preventive effect of cilostazol on the reduced sciatic nerve blood flow in the streptozotocin-induced diabetic rat

被引：0

作者：

Song, YD ^{[1
]}

Lee, H ^{[1
]}

Park, SW ^{[1
]}

Lee, HC ^{[1
]}

Cha, BS ^{[1
]}

Lim, SK ^{[1
]}

Kim, KR ^{[1
]}

Huh, KB ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Severance Hosp, Dept Internal Med,Seodaemun Ku, Seoul 120752, South Korea

来源：

RECENT ADVANCES ON THE PATHOGENESIS AND MANAGEMENT OF DIABETES MELLITUS: PROCEEDINGS OF THE 9TH KOREA-JAPAN SYMPOSIUM ON DIABETES MELLITUS, KYONGJU, KOREA, 11-12 APRIL 1997 | 1998年 / 1149卷

关键词：

cilostazol; diabetic neuropathy; nerve blood flow;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this study the effect of chronic cilostazol treatment on the sciatic nerve blood flow of streptozotocin-induced diabetic rats was investigated, Nerve blood flow was assessed using laser flowmetry. The results showed that the diabetic group had a significant reduction in nerve blood flow when compared with controls. The chronic cilostazol treatment of diabetic rats significantly improves the deficit in nerve blood flow observed in diabetic rats after 8 weeks of diabetes mellitus and could completely restore the deficit as compared to the control group. It is suggested that cilostazol is a potent vasodilator of rat peripheral nerves, and the treatment of diabetic rats with cilostazol may improve or prevent the changes of nerve blood flow.

引用

页码：414 / 416

页数：3