Difference of fibroblast growth factor receptor 1 expression among CA1-3 regions of the gerbil hippocampus after transient cerebral ischemia

被引：3
作者：
Yoo, Ki-Yeon [1 ,2 ]
Hwang, In Koo
Lee, Choong Hyun [1 ,2 ]
Choi, Jung Hoon [1 ,2 ]
Kwon, Seung-Hae
Kang, Il-Jun
You, Sang Guan
Kim, Young-Myeong
Won, Moo-Ho [1 ,2 ]
机构：
[1] Hallym Univ, Coll Med, Dept Anat & Neurobiol, Chunchon 200702, South Korea
[2] Hallym Univ, Coll Med, Inst Neurodegenerat & Neuroregenerat, Chunchon 200702, South Korea
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2010年 / 296卷 / 1-2期
关键词：
Ischemia; Hippocampus; Fibroblast growth factor receptor 1; Glial fibrillary acidic protein; Astrocytes; Gerbil; MESSENGER-RNA EXPRESSION; DELAYED NEURONAL DEATH; CENTRAL-NERVOUS-SYSTEM; FOREBRAIN ISCHEMIA; BRAIN-INJURY; CELLS; ASTROCYTES; DEPRESSION; INDUCTION; CORTEX;
D O I：
10.1016/j.jns.2010.06.018
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Fibroblast growth factors are important regulators of neuronal development. In this study, we observed fibroblast growth factor receptor 1 (FGFR1) immunoreactivity and its protein levels in the hippocampus proper (CA1-3 regions) of the gerbil at various time points after ischemia/reperfusion. In the sham-operated group, FGFR1 immunoreaction was not detected in the hippocampus proper. FGFR1 immunoreaction was first detected in non-pyramidal neurons in the CA1-3 region at 12 h and 1 day after ischemia/reperfusion. From 2 days after ischemia/reperfusion, FGFR1 immunoreaction was found in astrocytes, not in microglial cells, in the CA1 region: FGFR1 immunoreactivity and the number of astrocytes were significantly increased at 5 days post-ischemia. Western blot analysis revealed that FGFR1 protein levels were also increased from 1 day after ischemia/reperfusion. These results indicate that increase of FGFR1 in astrocytes of the ischemic CA1 region may be associated with gliosis followed by delayed neuronal death. (C) 2010 Elsevier B.V. All rights reserved.
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页码：13 / 21
页数：9
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