PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

被引：336

作者：

Abedi-Gaballu, Fereydoon ^{[1
,2
,3
]}

Dehghan, Gholamreza ^{[2
]}

Ghaffari, Maryam ^{[1
,2
]}

Yekta, Reza ^{[2
]}

Abbaspour-Ravasjani, Soheil ^{[4
]}

Baradaran, Behzad ^{[1
]}

Dolatabadi, Jafar Ezzati Nazhad ^{[5
]}

Hamblin, Michael R. ^{[6
,7
,8
]}

机构：

[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[2] Univ Tabriz, Dept Biol, Fac Nat Sci, Tabriz, Iran

[3] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[4] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[5] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[6] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[7] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA

[8] Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

APPLIED MATERIALS TODAY | 2018年 / 12卷

关键词：

PAMAM dendrimers; Targeted drug delivery; Gene delivery; Nanovehicles; Co-delivery; ENTRAPPED GOLD NANOPARTICLES; SOLID LIPID NANOPARTICLES; CO-DELIVERY; TARGETED DELIVERY; PANCREATIC-CANCER; ANTICANCER DRUG; RGD PEPTIDE; FOLIC-ACID; POLYAMIDOAMINE DENDRIMERS; PHOTOTHERMAL THERAPY;

D O I：

10.1016/j.apmt.2018.05.002

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have indiscriminate cytotoxicity that affects normal, as well as cancer cells. To overcome these problems, new more efficient nanosystems for drug delivery are increasingly being investigated. Polyamidoamine (PAMAM) dendrimers are an example of a versatile and reproducible type of nanocarrier that can be loaded with drugs, and modified by attaching target-specific ligands that recognize receptors that are over-expressed on cancer cells. PAMAM dendrimers with a high density of cationic charges display electrostatic interactions with nucleic acids (DNA, siRNA, miRNA, etc.), creating dendriplexes that can preserve the nucleic acids from degradation. Dendrimers are prepared by conducting several successive "generations" of synthetic reactions so their size can be easily controlled and they have good uniformity. Dendrimers are particularly well-suited to co-delivery applications (simultaneous delivery of drugs and/or genes). In the current review, we discuss dendrimer-based targeted delivery of drugs/genes and co-delivery systems mainly for cancer therapy. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：177 / 190

页数：14

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