Aqueous extract of Antrodia cinnamomea reduced high-fat diet-induced obesity in mice and suppressed adipogenesis in 3T3-L1 cells

被引:5
作者
Wang, Chih-Ling [1 ,2 ]
Huang, Wen-Cheng [1 ,3 ]
Chou, Cheng-Jen [4 ]
Lu, Mei-Kuang [5 ]
Huang, Ching-Jang [2 ]
Tsai, Jason [6 ]
Tsai, Po-Jung [1 ]
机构
[1] Natl Taiwan Normal Univ, Dept Human Dev & Family Studies, Taipei, Taiwan
[2] Natl Taiwan Univ, Dept Biochem Sci & Technol, Taipei, Taiwan
[3] Buddhist Tzuchi Med Fdn, Taipei Tzu Chi Hosp, Dept Pediat, New Taipei, Taiwan
[4] Taiwan Forestry Res Inst, Taipei, Taiwan
[5] Minist Hlth & Welf, Natl Res Inst Chinese Med, Taipei, Taiwan
[6] Lincoln Coll, Higher Educ, Complementary Med, Lincoln, England
关键词
Antrodia cinnamomea; Anti-obesity; Anti-adipogenesis; High-fat diet; 3T3-L1; adipocyte; MITOTIC CLONAL EXPANSION; ADIPOSE-TISSUE; C57BL/6; MICE; ADIPOCYTE DIFFERENTIATION; CAMPHORATA PROTECTS; METABOLIC SYNDROME; LIVER-DISEASE; ACID; ANTIOBESITY; COMPONENT;
D O I
10.1016/j.jff.2017.05.041
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
This study examined the anti-obesity and anti-adipogenic effects of Antrodia cinnamomea. Oral administration of aqueous extract of A. cinnamomea (ACW) significantly reduced high-fat diet-induced body weight gain and relative perirenal and mesenteric fat weight in C57BL/6J mice. Administration of ACW significantly reduced serum insulin, leptin, aspartate aminotransferase levels, HOMA-IR index, and hepatic cholesterol and triacylglycerol levels. Next, investigation of whether ACW and its polysaccharides (PS) and non-polysaccharides (NPS) subfractions possess anti-adipogenic action was conducted. Evidence showed that ACW, PS and NPS significantly inhibited lipid deposits in 3T3-L1 adipocytes. Both ACW and NPS significantly inhibited mitotic clonal expansion process of adipocyte differentiation. ACW and NPS also significantly decreased the expressions of PPAR gamma, C/EBP alpha, alpha P2 and FAS genes, while PS markedly inhibited PPAR gamma and alpha P2 gene expression. Our data indicated that ACW inhibits preadipocyte differentiation and adipogenesis. These results suggested that ACW may have therapeutic potential for obesity and related metabolic disorders. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:185 / 196
页数:12
相关论文
共 37 条
[1]   Treatment of non-alcoholic fatty liver disease [J].
Adams, LA ;
Angulo, P .
POSTGRADUATE MEDICAL JOURNAL, 2006, 82 (967) :315-322
[2]   Adipocyte and adipogenesis [J].
Ali, Aus Tariq ;
Hochfeld, Warren E. ;
Myburgh, Renier ;
Pepper, Michael S. .
EUROPEAN JOURNAL OF CELL BIOLOGY, 2013, 92 (6-7) :229-236
[3]   Cellular Models for Understanding Adipogenesis, Adipose Dysfunction, and Obesity [J].
Armani, Andrea ;
Mammi, Caterina ;
Marzolla, Vincenzo ;
Calanchini, Matilde ;
Antelmi, Antonella ;
Rosano, Giuseppe M. C. ;
Fabbri, Andrea ;
Caprio, Massimiliano .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2010, 110 (03) :564-572
[4]   Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors [J].
Boizard, M ;
Le Liepvre, X ;
Lemarchand, P ;
Foufelle, F ;
Ferré, P ;
Dugail, I .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (44) :29164-29171
[5]  
Cabezas J, 2012, NONALCOHOLIC FATTY L, V188N
[6]   Green tomato extract attenuates high-fat-diet-induced obesity through activation of the AMPK pathway in C57BL/6 mice [J].
Choi, Kyeong-Mi ;
Lee, Youn-Sun ;
Shin, Dong-Mi ;
Lee, Seunghyun ;
Yoo, Kwang-Sik ;
Lee, Mi Kyeong ;
Lee, Jae-Hak ;
Kim, Sun Yeou ;
Lee, Yong-Moon ;
Hong, Jin-Tae ;
Yun, Yeo-Pyo ;
Yoo, Hwan-Soo .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2013, 24 (01) :335-342
[7]   Antrodia camphorata ameliorates high-fat-diet induced hepatic steatosis via improving lipid metabolism and antioxidative status [J].
Chou, Mei-Chia ;
Chang, Renin ;
Hung, Yu-Han ;
Chen, Yi-Chen ;
Chiu, Chih-Hsien .
JOURNAL OF FUNCTIONAL FOODS, 2013, 5 (03) :1317-1325
[8]   Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans [J].
Friedman, Mendel .
FOODS, 2016, 5 (04) :1-40
[9]   Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds [J].
Geethangili, Madamanchi ;
Tzeng, Yew-Min .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, 2011 :1-17
[10]   The metabolic syndrome as a predictor of nonalcoholic fatty liver disease [J].
Hamaguchi, M ;
Kojima, T ;
Takeda, N ;
Nakagawa, T ;
Taniguchi, H ;
Fujii, K ;
Omatsu, T ;
Nakajima, T ;
Sarui, H ;
Shimazaki, M ;
Kato, T ;
Okuda, J ;
Ida, K .
ANNALS OF INTERNAL MEDICINE, 2005, 143 (10) :722-728