Immunotherapy of Melanoma

被引：14

作者：

Bender, Carolin

Hassel, Jessica C.

Enk, Alexander ^{[1
]}

机构：

[1] Univ Heidelberg Hosp, Dept Dermatol, Neuenheimer Feld 440, D-69120 Heidelberg, Germany

来源：

ONCOLOGY RESEARCH AND TREATMENT | 2016年 / 39卷 / 06期

关键词：

Immunotherapy; Immunooncology; Melanoma; CTLA-4; PD-1; TUMOR-INFILTRATING LYMPHOCYTES; ADOPTIVE CELL THERAPY; METASTATIC MELANOMA; CANCER-IMMUNOTHERAPY; T-CELLS; PHASE-II; IPILIMUMAB; PD-1; BRAF; INTERLEUKIN-2;

D O I：

10.1159/000446716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Arising from melanocytes in skin, mucosal membranes, eye, and meninges, melanoma is a tumor that has been associated with poor prognosis in advanced disease stages. Given the poor response to chemotherapy and radiation therapy, new treatment approaches with targeted therapy, immunotherapy, and adoptive T-cell therapy have revolutionized the standard of care for patients with advanced melanoma. This review provides a short overview of past, present, and future immunotherapeutic approaches and their limitations, with a focus on new combination agents in early clinical trials. (C) 2016 S. Karger GmbH, Freiburg

引用

页码：369 / 376

页数：8

共 72 条

[1] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[2] Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma [J].

Andtbacka, Robert H. I. ;

Kaufman, Howard L. ;

Collichio, Frances ;

Amatruda, Thomas ;

Senzer, Neil ;

Chesney, Jason ;

Delman, Keith A. ;

Spitler, Lynn E. ;

Puzanov, Igor ;

Agarwala, Sanjiv S. ;

Milhem, Mohammed ;

Cranmer, Lee ;

Curti, Brendan ;

Lewis, Karl ;

Ross, Merrick ;

Guthrie, Troy ;

Linette, Gerald P. ;

Daniels, Gregory A. ;

Harrington, Kevin ;

Middleton, Mark R. ;

Miller, Wilson H., Jr. ;

Zager, Jonathan S. ;

Ye, Yining ;

Yao, Bin ;

Li, Ai ;

Doleman, Susan ;

VanderWalde, Ari ;

Gansert, Jennifer ;

Coffin, Robert S. .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (25) :2780-U98

[3]

[Anonymous], 2009, COMMON TERMINOLOGY C

[4] Adjuvant therapy of melanoma with interferon: lessons of the past decade [J].

Ascierto, Paolo A. ;

Kirkwood, John M. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2008, 6 (1)

[5] Rationale for anti-OX40 cancer immunotherapy [J].

Aspeslagh, Sandrine ;

Postel-Vinay, Sophie ;

Rusakiewicz, Sylvie ;

Soria, Jean-Charles ;

Zitvogel, Laurence ;

Marabelle, Aurelien .

EUROPEAN JOURNAL OF CANCER, 2016, 52 :50-66

[6] Final Version of 2009 AJCC Melanoma Staging and Classification [J].

Balch, Charles M. ;

Gershenwald, Jeffrey E. ;

Soong, Seng-jaw ;

Thompson, John F. ;

Atkins, Michael B. ;

Byrd, David R. ;

Buzaid, Antonio C. ;

Cochran, Alistair J. ;

Coit, Daniel G. ;

Ding, Shouluan ;

Eggermont, Alexander M. ;

Flaherty, Keith T. ;

Gimotty, Phyllis A. ;

Kirkwood, John M. ;

McMasters, Kelly M. ;

Mihm, Martin C., Jr. ;

Morton, Donald L. ;

Ross, Merrick I. ;

Sober, Arthur J. ;

Sondak, Vernon K. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (36) :6199-6206

[7] Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma: Intent-to-Treat Analysis and Efficacy after Failure to Prior Immunotherapies [J].

Besser, Michal J. ;

Shapira-Frommer, Ronnie ;

Itzhaki, Orit ;

Treves, Avraham J. ;

Zippel, Douglas B. ;

Levy, Daphna ;

Kubi, Adva ;

Shoshani, Noa ;

Zikich, Dragoslav ;

Ohayon, Yaara ;

Ohayon, Daniel ;

Shalmon, Bruria ;

Markel, Gal ;

Yerushalmi, Ronit ;

Apter, Sara ;

Ben-Nun, Alon ;

Ben-Ami, Eytan ;

Shimoni, Avichai ;

Nagler, Arnon ;

Schachter, Jacob .

CLINICAL CANCER RESEARCH, 2013, 19 (17) :4792-4800

[8] Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients [J].

Besser, Michal J. ;

Shapira-Frommer, Ronnie ;

Treves, Avraham J. ;

Zippel, Dov ;

Itzhaki, Orit ;

Hershkovitz, Liat ;

Levy, Daphna ;

Kubi, Adva ;

Hovav, Einat ;

Chermoshniuk, Natalia ;

Shalmon, Bruria ;

Hardan, Izhar ;

Catane, Raphael ;

Markel, Gal ;

Apter, Sara ;

Ben-Nun, Alon ;

Kuchuk, Iryna ;

Shimoni, Avichai ;

Nagler, Arnon ;

Schachter, Jacob .

CLINICAL CANCER RESEARCH, 2010, 16 (09) :2646-2655

[9] Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma [J].

Castle, John C. ;

Loewer, Martin ;

Boegel, Sebastian ;

de Graaf, Jos ;

Bender, Christian ;

Tadmor, Arbel D. ;

Boisguerin, Valesca ;

Bukur, Thomas ;

Sorn, Patrick ;

Paret, Claudia ;

Diken, Mustafa ;

Kreiter, Sebastian ;

Tureci, Ozlem ;

Sahin, Ugur .

BMC GENOMICS, 2014, 15

[10] Exploiting the Mutanome for Tumor Vaccination [J].

Castle, John C. ;

Kreiter, Sebastian ;

Diekmann, Jan ;

Loewer, Martin ;

Van de Roemer, Niels ;

de Graaf, Jos ;

Selmi, Abderraouf ;

Diken, Mustafa ;

Boegel, Sebastian ;

Paret, Claudia ;

Koslowski, Michael ;

Kuhn, Andreas N. ;

Britten, Cedrik M. ;

Huber, Christoph ;

Tuereci, Oezlem ;

Sahin, Ugur .

CANCER RESEARCH, 2012, 72 (05) :1081-1091

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