Pretreatment Plasma D-Dimer, Fibrinogen, and Platelet Levels Significantly Impact Prognosis in Patients With Epithelial Ovarian Cancer Independently of Venous Thromboembolism

被引:70
|
作者
Man, Ya-Nan [1 ,2 ]
Wang, Ya-Nan [1 ]
Hao, Jian [1 ]
Liu, Xiaohui [1 ]
Liu, Chang [1 ]
Zhu, Cuihong [1 ]
Wu, Xiong-Zhi [1 ]
机构
[1] Tianjin Med Univ, Canc Inst & Hosp, Key Lab Canc Prevent & Therapy, Zhong Shan Men In Patient Dept, Tianjin 300060, Peoples R China
[2] Tianjin Med Univ, Hosp 2, Dept Radiat Oncol, Tianjin 300060, Peoples R China
关键词
Thrombocytosis; D-dimer; Fibrinogen; Venous thromboembolism; Epithelial ovarian cancer; Prognosis; BLOOD-COAGULATION; ANTITHROMBIN-III; SURVIVAL; LUNG; THROMBOCYTOSIS; ACTIVATION; MARKERS; HYPERFIBRINOGENEMIA; PROGRESSION; METASTASIS;
D O I
10.1097/IGC.0000000000000303
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: The study aimed to evaluate the prognostic value of pretreatment plasma dimerized plasmin fragment D (D-dimer), fibrinogen, and platelet levels in epithelial ovarian cancer (EOC) after adjusting for venous thromboembolism (VTE) and to screen out the patients with the greatest risk for poor prognosis. Methods: The study comprised 190 patients with EOC. The plasma D-dimer, fibrinogen, and platelet levels were examined before treatment and analyzed with patient clinicopathological parameters, progression-free survival (PFS), and overall survival (OS). The survival analysis was performed using the Kaplan-Meier method, and prognostic factors were assessed using the Cox proportional hazards regression model. Results: The incidences of elevated plasma D-dimer levels, hyperfibrinogenemia, and thrombocytosis were 40%, 42.11%, and 45.26%, respectively. Elevated plasma D-dimer level, hyperfibrinogenemia, and thrombocytosis were associated with advanced tumor stage (P < 0.001, P = 0.013, P < 0.001). In addition, the elevated plasma D-dimer levels were associated with macroscopic postoperative residual disease (P = 0.002) and VTE events (P = 0.006). In multivariate Cox regression model, plasma D-dimer, fibrinogen, and platelet levels were identified as independent prognostic factors for OS (P = 0.039, P = 0.002, and P = 0.049). However, plasma fibrinogen and platelet levels, but not D-dimer levels, had independent prognostic value for PFS (P = 0.012 and P = 0.022). Patients with at least any 2 abnormalities of plasma D-dimer, fibrinogen, and platelet levels showed shorter PFS and OS than did patients with at most 1 abnormality of 3 parameters (P < 0.001). Conclusions: Pretreatment plasma D-dimer, fibrinogen, and platelet levels, which impact prognosis independently of VTE, were demonstrated to be potential markers to predict disease progression and surgery outcome in patients with EOC. The combined use of plasma D-dimer, fibrinogen, and platelet levels may help to identify the high-risk populations for treatment decisions.
引用
收藏
页码:24 / 32
页数:9
相关论文
共 50 条
  • [21] High D-dimer levels are associated with poor prognosis in cancer patients
    Ay, Cihan
    Dunkler, Daniela
    Pirker, Robert
    Thaler, Johannes
    Quehenberger, Peter
    Wagner, Oswald
    Zielinski, Christoph
    Pabinger, Ingrid
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2012, 97 (08): : 1158 - 1164
  • [22] Impact of pretreatment plasma D-dimer levels and its perioperative change on prognosis in operable esophageal squamous cell carcinoma
    Li, Jianbo
    Zheng, Zhifan
    Fang, Min
    ONCOTARGET, 2017, 8 (45) : 79537 - 79545
  • [23] Could plasma D-dimer levels be a predictive marker for prognosis in lung cancer?
    Kurt, Bahar
    Kurt, Ozlem Kar
    Kalayci, Defne
    Tug, Tuncer
    Talay, Fahrettin
    TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX, 2013, 61 (04): : 269 - 274
  • [24] Comment on "significant decrease in plasma d-dimer levels and mean platelet volume after a 3-month treatment with rosuvastatin in patients with venous thromboembolism"
    Coban, Erkan
    CLINICAL CARDIOLOGY, 2022, 45 (10) : 975 - 975
  • [25] MEASURING THE PREOPERATIVE D-DIMER CONCENTRATION IN PATIENTS WITH LUNG CANCER TO SCREEN FOR VENOUS THROMBOEMBOLISM
    Kanauchi, N.
    Isamu, W.
    RESPIROLOGY, 2016, 21 : 112 - 112
  • [26] Plasma Fibrinogen Levels and Prognosis in Patients with Ovarian Cancer: A Multicenter Study
    Polterauer, Stephan
    Grimm, Christoph
    Seebacher, Veronika
    Concin, Nicole
    Marth, Christian
    Tomovski, Caroline
    Husslein, Heinrich
    Leipold, Heinz
    Hefler-Frischmuth, Katrin
    Tempfer, Clemens
    Reinthaller, Alexander
    Hefler, Lukas
    ONCOLOGIST, 2009, 14 (10): : 979 - 985
  • [27] Tissue factor pathway inhibitor 2 as a serum marker for diagnosing asymptomatic venous thromboembolism in patients with epithelial ovarian cancer and positive D-dimer results
    Miyake, Ryuta
    Yamada, Yuki
    Yamanaka, Shoichiro
    Kawaguchi, Ryuji
    Ootake, Norihisa
    Myoba, Shohei
    Kobayashi, Hiroshi
    MOLECULAR AND CLINICAL ONCOLOGY, 2022, 16 (02)
  • [28] High D-dimer levels at presentation in patients with venous thromboembolism is a marker of adverse clinical outcomes
    Paneesha, S.
    Cheyne, E.
    French, K.
    Bacchu, S.
    Borg, A.
    Rose, P.
    BRITISH JOURNAL OF HAEMATOLOGY, 2006, 135 (01) : 85 - 90
  • [29] Does D-dimer levels on admission predicts venous thromboembolism in patients with COVID-19?
    Louhaichi, Sabrine
    Ferchichi, Mariem
    Khalfallah, Ikbelle
    Boubaker, Nouha
    Belkhir, Safa
    Ammar, Jamel
    Hamdi, Besma
    Hamzaoui, Agnes
    EUROPEAN RESPIRATORY JOURNAL, 2021, 58
  • [30] Clinical Suspicion and D-Dimer Levels in Venous Thromboembolism Patients With Low and High Clot Burden
    Singer, A. J.
    Zheng, H.
    Kabrhel, C.
    Parry, B. A.
    Chang, A. M.
    Fermann, G. J.
    LoVecchio, F.
    Francis, S. J.
    Kakeng, A. T., Jr.
    Zeserson, E. M.
    ANNALS OF EMERGENCY MEDICINE, 2017, 70 (04) : S31 - S31