Gain in 1q is a common abnormality in phyllodes tumours of the breast

被引：27

作者：

Jee, KJ

Gong, GY

Ahn, SH

Park, JM

Knuutila, S

机构：

[1] Univ Helsinki, Haartman Inst, Dept Pathol, FIN-00014 Helsinki, Finland

[2] Haartman Inst, Dept Med Genet, Helsinki, Finland

[3] Univ Helsinki, Cent Hosp, Helsinki, Finland

[4] Univ Ulsan, Coll Med, Dept Pathol, ASAN Med Ctr, Seoul, South Korea

[5] Univ Ulsan, Coll Med, Dept Gen Surg, ASAN Med Ctr, Seoul, South Korea

[6] Univ Ulsan, Coll Med, Dept Diagnost Radiol, ASAN Med Ctr, Seoul, South Korea

来源：

ANALYTICAL CELLULAR PATHOLOGY | 2003年 / 25卷 / 02期

关键词：

phyllodes tumour; comparative genomic hybridization; allelic loss on 3p; chromosome; 1q21-q23;

D O I：

10.1155/2003/803192

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We studied DNA copy number changes by CGH and allelic imbalance (AI) on 3p by LOH analysis on 22 phyllodes tumours (PT) of the breast in order to gain insight into the genetic basis of tumour progression in PT. Copy number changes were observed in 14 cases (63%). Gain in 1q with 1q21-23 as the minimal overlapping area was seen in 12 cases (55%). The gain was observed both in benign and malignant tumours. Our study did not reveal any DNA copy number changes or allelic loss on 3p. The results suggest that DNA copy number changes are not associated with the histological grade or clinical behaviour of PT and the chromosomal changes on 3p appear to be rare. Colour figure can be viewed on http://www.esacp.org/acp/2003/25-2/jee.htm.

引用

页码：89 / 93

页数：5

共 20 条

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