Complete regression of a previously untreated melanoma brain metastasis with ipilimumab

被引：58
作者：
Schartz, Noel E. C.
Farges, Cecile [2 ]
Madelaine, Isabelle
Bruzzoni, Heriberto [3 ]
Calvo, Fabien [3 ]
Hoos, Axel [4 ]
Lebbe, Celeste [1 ]
机构：
[1] Univ Paris 07, Hop St Louis, AP HP, Skin Res Ctr,Dept Dermatol,INSERM,U976, F-75475 Paris 10, France
[2] Hop St Louis, AP HP, Dept Radiol, Paris, France
[3] Hop St Louis, AP HP, CIC Ctr Clin Invest, Paris, France
[4] Bristol Myers Squibb Co, Wallingford, CT 06492 USA
来源：
MELANOMA RESEARCH | 2010年 / 20卷 / 03期
关键词：
brain metastasis; ipilimumab; melanoma; VACCINATION; BLOCKADE; RESPONSES; ANTIGEN-4; ANTIBODY;
D O I：
10.1097/CMR.0b013e3283364a37
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Anecdotal cases of partial or complete responses have been reported after ipilimumab therapy for stage IV melanoma with brain metastasis treated earlier by surgery or radiosurgery. We report the first case of ipilimumab monotherapy resulting in durable complete remission of untreated, progressive brain metastases in a patient with stage IV melanoma. This case and earlier reports provide support for the further evaluation of ipilimumab in melanoma patients with brain metastasis. Melanoma Res 20:247-250 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：247 / 250
页数：4
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