CALL FOR PAPERS Renal Hypoxia Hypoxia as a key player in the AKI-to-CKD transition

被引:207
作者
Tanaka, Shinji [1 ]
Tanaka, Tetsuhiro [1 ]
Nangaku, Masaomi [1 ]
机构
[1] Univ Tokyo, Grad Sch, Div Nephrol & Endocrinol, Tokyo 1138655, Japan
基金
日本学术振兴会;
关键词
hypoxia; hypoxia-inducible factor; acute kidney injury; chronic kidney disease; AKI-to-CKD transition; ACUTE-KIDNEY-INJURY; ENDOTHELIAL GROWTH-FACTOR; ISCHEMIA-REPERFUSION INJURY; INCREASED OXYGEN-CONSUMPTION; EPITHELIAL-CELLS REPAIR; INDUCIBLE FACTOR-1-ALPHA; MOUSE MODEL; RAT-KIDNEY; MICROVASCULAR RAREFACTION; CAPILLARY RAREFACTION;
D O I
10.1152/ajprenal.00425.2014
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Recent clinical and animal studies have shown that acute kidney injury (AKI), even if followed by complete recovery of renal function, can eventually result in chronic kidney disease (CKD). Renal hypoxia is emerging as a key player in the pathophysiology of the AKI-toCKD transition. Capillary rarefaction after AKI episodes induces renal hypoxia, which can in turn profoundly affect tubular epithelial cells, (myo) fibroblasts, and inflammatory cells, culminating in tubulointerstitial fibrosis, i. e., progression to CKD. Damaged tubular epithelial cells that fail to redifferentiate might supply a decreased amount of vascular endothelial growth factor and contribute to capillary rarefaction, thus aggravating hypoxia and forming a vicious cycle. Mounting evidence also shows that epigenetic changes are closely related to renal hypoxia in the pathophysiology of CKD progression. Animal experiments suggest that targeting hypoxia is a promising strategy to block the transition from AKI to CKD. However, the precise mechanisms by which hypoxia induces the AKI-toCKD transition and by which hypoxia-inducible factor activation can exert a protective effect in this context should be clarified in further studies.
引用
收藏
页码:F1187 / F1195
页数:9
相关论文
共 144 条
[1]   Fluorescent Microangiography Is a Novel and Widely Applicable Technique for Delineating the Renal Microvasculature [J].
Advani, Andrew ;
Connelly, Kim A. ;
Yuen, Darren A. ;
Zhang, Yanling ;
Advani, Suzanne L. ;
Trogadis, Judy ;
Kabir, M. Golam ;
Shachar, Etai ;
Kuliszewski, Michael A. ;
Leong-Poi, Howard ;
Stewart, Duncan J. ;
Gilbert, Richard E. .
PLOS ONE, 2011, 6 (10)
[2]   Outcomes following diagnosis of acute renal failure in US veterans: focus on acute tubular necrosis [J].
Amdur, Richard L. ;
Chawla, Lakhmir S. ;
Amodeo, Susan ;
Kimmel, Paul L. ;
Palant, Carlos E. .
KIDNEY INTERNATIONAL, 2009, 76 (10) :1089-1097
[3]   Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice [J].
Asada, Nariaki ;
Takase, Masayuki ;
Nakamura, Jin ;
Oguchi, Akiko ;
Asada, Misako ;
Suzuki, Norio ;
Yamarnura, Ken-ichi ;
Nagoshi, Narihito ;
Shibata, Shinsuke ;
Rao, Tata Nageswara ;
Fehling, Hans Joerg ;
Fukatsu, Atsushi ;
Minegishi, Naoko ;
Kita, Toru ;
Kimura, Takeshi ;
Okano, Hideyuki ;
Yamamoto, Masayuki ;
Yanagita, Motoko .
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (10) :3981-3990
[4]   Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes [J].
Ascon, Miguel ;
Ascon, Dolores B. ;
Liu, Manchang ;
Cheadle, Chris ;
Sarkar, Chaitali ;
Racusen, Lorraine ;
Hassoun, Heitham T. ;
Rabb, Hamid .
KIDNEY INTERNATIONAL, 2009, 75 (05) :526-535
[5]   3-5 Year longitudinal follow-up of pediatric patients after acute renal failure [J].
Askenazi, DJ ;
Feig, DI ;
Graham, NM ;
Hui-Stickle, S ;
Goldstein, SL .
KIDNEY INTERNATIONAL, 2006, 69 (01) :184-189
[6]   The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function [J].
Basile, D. P. .
KIDNEY INTERNATIONAL, 2007, 72 (02) :151-156
[7]   Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor [J].
Basile, David P. ;
Fredrich, Katherine ;
Chelladurai, Bhadrani ;
Leonard, Ellen C. ;
Parrish, Alan R. .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2008, 294 (04) :F928-F936
[8]   Pathophysiology of Acute Kidney Injury [J].
Basile, David P. ;
Anderson, Melissa D. ;
Sutton, Timothy A. .
COMPREHENSIVE PHYSIOLOGY, 2012, 2 (02) :1303-1353
[9]   Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury [J].
Basile, David P. ;
Friedrich, Jessica L. ;
Spahic, Jasmina ;
Knipe, Nicole ;
Mang, Henry ;
Leonard, Ellen C. ;
Changizi-Ashtiyani, Saeed ;
Bacallao, Robert L. ;
Molitoris, Bruce A. ;
Sutton, Timothy A. .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2011, 300 (03) :F721-F733
[10]   Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage [J].
Basile, DP ;
Donohoe, DL ;
Roethe, K ;
Mattson, DL .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (02) :F338-F348