New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus Aspergillus sp. CYH26

被引：6

作者：

Pan, Guojun ^{[1
]}

Li, Yanling ^{[1
]}

Che, Xinyu ^{[2
]}

Tian, Dan ^{[2
]}

Han, Wenjie ^{[1
]}

Wang, Zimin ^{[1
]}

Zhao, Yanfen ^{[1
]}

Ren, Shuang ^{[1
]}

Xu, Yiru ^{[1
]}

Hao, Gangping ^{[1
]}

Guo, Mengfei ^{[3
]}

Xiao, Na ^{[2
,4
]}

Kong, Fandong ^{[3
]}

机构：

[1] Shandong First Med Univ, Shandong Acad Med Sci, Coll Life Sci, Tai An, Shandong, Peoples R China

[2] Shandong Agr Univ, Coll Agron, State Key Lab Crop Biol, Tai An, Shandong, Peoples R China

[3] Guangxi Univ Nationalities, Key Lab Chem & Engn Forest Prod,State Ethn Affair, Guangxi Collaborat Innovat Ctr Chem & Engn Forest, Sch Chem & Chem Engn,Guangxi Key Lab Chem & Engn, Nanning, Peoples R China

[4] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

Aspergillus sp; CYH26; thio-compounds; monoterpenes; anti-inflammatory activity; fungus;

D O I：

10.3389/fmicb.2021.668938

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two new thio-compounds named aspergerthinol A and B (1 and 2) and two new monoterpenes named aspergerthinacids A and B (3 and 4) were isolated from the fungus Aspergillus sp. CYH26 from the rhizosphere soil of Cynanchum bungei Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculations. Compounds 1 and 2 represented a new family of sulfur containing natural products with a 3-methyl-4H-cyclopenta[b]thiophen-4-one skeleton. Compounds 1-4 showed inhibitory activities against nitric oxide (NO) with IC50 values of 38.0, 19.8, 46.3, and 56.6 mu M, respectively.

引用

页数：6

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