Tamoxifen-loaded silk fibroin electrospun fibers

被引：18
作者：
Liu, Wen [1 ]
Wang, Yu [1 ]
Yao, Jinrong [1 ]
Shao, Zhengzhong [1 ]
Chen, Xin [1 ]
机构：
[1] Fudan Univ, Dept Macromol Sci, Collaborat Innovat Ctr Polymers & Polymer Composi, State Key Lab Mol Engn Polymers,Adv Mat Lab, Shanghai 200433, Peoples R China
来源：
MATERIALS LETTERS | 2016年 / 178卷
基金：
中国国家自然科学基金;
关键词：
Polymeric composites; Proteins; Electrospinning; Fiber technology; Drug-loading; Controlled release; DRUG-DELIVERY SYSTEM; ANTIBACTERIAL ACTIVITY; NANOFIBERS; RELEASE;
D O I：
10.1016/j.matlet.2016.04.177
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this article, the regenerated silk fibroin/2-hydroxypropyl-beta-cyclodextrin/tamoxifen (RSF/2-HP-beta-CD/TAM) composite fibers are successfully prepared via an electrospinning technique. 2-HP-beta-CD/TAM inclusion complex is firstly formed to increase the TAM solubility in the spinning dope. The morphology of the electrospun fibers is investigated, which shows the addition of 2-HP-beta-CD/TAM significantly decreases the fiber diameter. Raman spectra confirm the effective loading of TAM in the resulting electrospun fibers. The drug release behavior of RSF/2-HP-beta-CD/TAM composite fibers indicates that the TAM loaded in such a composite fibers is able to perform a sustainable release. Thus, the TAM-loaded RSF electrospun fibers presented in this report may have a great potential as be a promising local drug delivery system for breast cancer therapy. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：31 / 34
页数：4
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