Melatonin production: Proteasomal proteolysis in serotonin N-acetyltransferase regulation

被引：248

作者：

Gastel, JA ^{[1
]}

Roseboom, PH ^{[1
]}

Rinaldi, PA ^{[1
]}

Weller, JL ^{[1
]}

Klein, DC ^{[1
]}

机构：

[1] NICHHD, Sect Neuroendocrinol, Dev Neurobiol Lab, NIH, Bethesda, MD 20892 USA

来源：

SCIENCE | 1998年 / 279卷 / 5355期

关键词：

D O I：

10.1126/science.279.5355.1358

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The nocturnal increase in circulating melatonin in vertebrates is regulated bg, 10- to 100-fold increases in pineal serotonin N-acetyltransferase (AA-NAT) activity. Changes in the amount of AA-NAT protein were shown to parallel changes in AA-NAT activity. When neural stimulation was switched off by either light exposure or L-propranalol-induced beta-adrenergic blockade, both AA-NAT activity and protein decreased rapidly. Effects of L-propranolol were blocked in vitro by dibutyryl adenosine 3',5'-monophasphate (cAMP) or inhibitors of proteasomal proteolysis. This result indicates that adrenergic-cAMP regulation of AA-NAT is mediated by rapid reversible control af selective proteasomal proteolysis. Similar proteasome-based mechanisms may function widely as selective molecular switches in vertebrate neural systems.

引用

页码：1358 / 1360

页数：3

共 43 条

[1]

Arendt J., 1995, MELATONIN MAMMALIAN, P1

[2] PINEAL-GLAND - NEUROCHEMICAL TRANSDUCER [J].

AXELROD, J .

SCIENCE, 1974, 184 (4144) :1341-1348

[3] The rat arylalkylamine N-acetyltransferase gene promoter - cAMP activation via a cAMP-responsive element-CCAAT complex [J].

Baler, R ;

Covington, S ;

Klein, DC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (11) :6979-6985

[4]

Bernard M, 1997, J NEUROCHEM, V68, P213

[5] REGULATION OF PINEAL RHYTHMS IN CHICKENS - REFRACTORY PERIOD AND NONVISUAL LIGHT PERCEPTION [J].

BINKLEY, S ;

MACBRIDE, SE ;

KLEIN, DC ;

RALPH, CL .

ENDOCRINOLOGY, 1975, 96 (04) :848-853

[6] PINEAL MELATONIN SECRETION DRIVES THE REPRODUCTIVE RESPONSE TO DAYLENGTH IN THE EWE [J].

BITTMAN, EL ;

DEMPSEY, RJ ;

KARSCH, FJ .

ENDOCRINOLOGY, 1983, 113 (06) :2276-2283

[7] Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors [J].

Bogyo, M ;

McMaster, JS ;

Gaczynska, M ;

Tortorella, D ;

Goldberg, AL ;

Ploegh, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (13) :6629-6634

[8] PINEAL-GLAND - 24-HOUR RHYTHM IN NOREPINEPHRINE TURNOVER [J].

BROWNSTEIN, M ;

AXELROD, J .

SCIENCE, 1974, 184 (4133) :163-165

[9] PINEAL SEROTONIN N-ACETYLTRANSFERASE - EXPRESSION CLONING AND MOLECULAR ANALYSIS [J].

COON, SL ;

ROSEBOOM, PH ;

BALER, R ;

WELLER, JL ;

NAMBOODIRI, MAA ;

KOONIN, EV ;

KLEIN, DC .

SCIENCE, 1995, 270 (5242) :1681-1683

[10] MUSCLE PROTEIN WASTE IN TUMOR-BEARING RATS IS EFFECTIVELY ANTAGONIZED BY A BETA(2)-ADRENERGIC AGONIST (CLENBUTEROL) - ROLE OF THE ATP-UBIQUITIN-DEPENDENT PROTEOLYTIC PATHWAY [J].

COSTELLI, P ;

GARCIAMARTINEZ, C ;

LLOVERA, M ;

CARBO, N ;

LOPEZSORIANO, FJ ;

AGELL, N ;

TESSITORE, L ;

BACCINO, FM ;

ARGILES, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (05) :2367-2372

← 1 2 3 4 5 →